Molecular Signatures of Cardiac Defects in Down Syndrome Lymphoblastoid Cell Lines Suggest Altered Ciliome and Hedgehog Pathways

Clémentine Ripoll; Isabelle Rivals; Emilie Ait Yahya-Graison; Luce Dauphinot; Evelyne Paly; Clothilde Mircher; Aimé Ravel; Yann Grattau; Henri Bléhaut; André Mégarbane; Guy Dembour; Bénédicte de Fréminville; Renaud Touraine; Nicole Créau; Marie Claude Potier; Jean Maurice Delabar

doi:10.1371/journal.pone.0041616

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Research Article

Molecular Signatures of Cardiac Defects in Down Syndrome Lymphoblastoid Cell Lines Suggest Altered Ciliome and Hedgehog Pathways

Clémentine Ripoll,

Affiliation Univ Paris Diderot, Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative, EAC4413 CNRS, Paris, France
⨯
Isabelle Rivals,

Affiliation Equipe de Statistique Appliquée, ESPCI ParisTech, Paris, France
⨯
Emilie Ait Yahya-Graison,

Affiliation Univ Paris Diderot, Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative, EAC4413 CNRS, Paris, France
⨯
Luce Dauphinot,

Affiliation CRICM, CNRS UMR7225, INSERM UMR975, UPMC Hôpital de la Pitié-Salpêtrière, Paris, France
⨯
Evelyne Paly,

Affiliation Univ Paris Diderot, Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative, EAC4413 CNRS, Paris, France
⨯
Clothilde Mircher,

Affiliation Institut Médical Jérôme Lejeune et Fondation Jérome Lejeune, Paris, France
⨯
Aimé Ravel,

Affiliation Institut Médical Jérôme Lejeune et Fondation Jérome Lejeune, Paris, France
⨯
Yann Grattau,

Affiliation Institut Médical Jérôme Lejeune et Fondation Jérome Lejeune, Paris, France
⨯
Henri Bléhaut,

Affiliation Institut Médical Jérôme Lejeune et Fondation Jérome Lejeune, Paris, France
⨯
André Mégarbane,

Affiliations Institut Médical Jérôme Lejeune et Fondation Jérome Lejeune, Paris, France, Unité de Génétique Médicale, Faculté de Médecine, Université Saint-Joseph, Beirut, Lebanon
⨯
Guy Dembour,

Affiliation Cardiologie pédiatrique, Cliniques Universitaires St Luc, Bruxelles, Belgique
⨯
Bénédicte de Fréminville,

Affiliation Service de Génétique, Centre Hospitalier Universitaire de Saint-Etienne, Saint-Etienne, France
⨯
Renaud Touraine,

Affiliation Service de Génétique, Centre Hospitalier Universitaire de Saint-Etienne, Saint-Etienne, France
⨯
Nicole Créau,

Affiliation Univ Paris Diderot, Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative, EAC4413 CNRS, Paris, France
⨯
Marie Claude Potier,

Affiliation CRICM, CNRS UMR7225, INSERM UMR975, UPMC Hôpital de la Pitié-Salpêtrière, Paris, France
⨯
[ ... ],
Jean Maurice Delabar

* E-mail: delabar@univ-paris-diderot.fr

Affiliation Univ Paris Diderot, Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative, EAC4413 CNRS, Paris, France
⨯
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Molecular Signatures of Cardiac Defects in Down Syndrome Lymphoblastoid Cell Lines Suggest Altered Ciliome and Hedgehog Pathways

Clémentine Ripoll,
Isabelle Rivals,
Emilie Ait Yahya-Graison,
Luce Dauphinot,
Evelyne Paly,
Clothilde Mircher,
Aimé Ravel,
Yann Grattau,
Henri Bléhaut,
André Mégarbane

Published: August 9, 2012
https://doi.org/10.1371/journal.pone.0041616

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Down syndrome
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Hedgehog signaling
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