The Obesity-Related Peptide Leptin Sensitizes Cardiac Mitochondria to Calcium-Induced Permeability Transition Pore Opening and Apoptosis

Open Access

Peer-reviewed

Research Article

Eduardo Martinez-Abundis,

Affiliation Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
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Venkatesh Rajapurohitam,

Affiliation Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
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James V. Haist,

Affiliation Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
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Xiaohong T. Gan,

Affiliation Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
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Morris Karmazyn

* E-mail: Morris.Karmazyn@schulich.uwo.ca

Affiliation Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
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Leptin
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Mitochondria
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Muscle cells
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Apoptosis
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Phosphorylation
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Heart failure
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Cardiomyocytes
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Obesity
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