Mutation Discovery in Regions of Segmental Cancer Genome Amplifications with CoNAn-SNV: A Mixture Model for Next Generation Sequencing of Tumors

Anamaria Crisan; Rodrigo Goya; Gavin Ha; Jiarui Ding; Leah M. Prentice; Arusha Oloumi; Janine Senz; Thomas Zeng; Kane Tse; Allen Delaney; Marco A. Marra; David G. Huntsman; Martin Hirst; Sam Aparicio; Sohrab Shah

doi:10.1371/journal.pone.0041551

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Open Access

Peer-reviewed

Research Article

Mutation Discovery in Regions of Segmental Cancer Genome Amplifications with CoNAn-SNV: A Mixture Model for Next Generation Sequencing of Tumors

Anamaria Crisan,

Affiliation Department of Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada
⨯
Rodrigo Goya,

Affiliations Department of Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada, Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
⨯
Gavin Ha,

Affiliation Department of Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada
⨯
Jiarui Ding,

Affiliations Department of Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada, Department of Computer Science, University of British Columbia, Vancouver, British Columbia, Canada
⨯
Leah M. Prentice,

Affiliation Department of Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada
⨯
Arusha Oloumi,

Affiliation Department of Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada
⨯
Janine Senz,

Affiliation Department of Computer Science, University of British Columbia, Vancouver, British Columbia, Canada
⨯
Thomas Zeng,

Affiliation Department of Computer Science, University of British Columbia, Vancouver, British Columbia, Canada
⨯
Kane Tse,

Affiliation Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
⨯
Allen Delaney,

Affiliation Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
⨯
Marco A. Marra,

Affiliation Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
⨯
David G. Huntsman,

Affiliation Centre for Translational and Applied Genomics, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
⨯
Martin Hirst,

Affiliation Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
⨯
Sam Aparicio,

Affiliation Department of Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada
⨯
Sohrab Shah

* E-mail: sshah@bccrc.ca

Affiliations Department of Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
⨯

Mutation Discovery in Regions of Segmental Cancer Genome Amplifications with CoNAn-SNV: A Mixture Model for Next Generation Sequencing of Tumors

Anamaria Crisan,
Rodrigo Goya,
Gavin Ha,
Jiarui Ding,
Leah M. Prentice,
Arusha Oloumi,
Janine Senz,
Thomas Zeng,
Kane Tse,
Allen Delaney

Published: August 16, 2012
https://doi.org/10.1371/journal.pone.0041551

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