Development of a High-Throughput Assay for Identifying Inhibitors of TBK1 and IKKε

Jessica E. Hutti; Melissa A. Porter; Adam W. Cheely; Lewis C. Cantley; Xiaodong Wang; Dmitri Kireev; Albert S. Baldwin; William P. Janzen

doi:10.1371/journal.pone.0041494

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Peer-reviewed

Research Article

Development of a High-Throughput Assay for Identifying Inhibitors of TBK1 and IKKε

Jessica E. Hutti,

Affiliation Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, North Carolina, United States of America
⨯
Melissa A. Porter,

Affiliation Division of Medicinal Chemistry and Natural Products, Center for Integrated Chemical Biology and Drug Discovery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
⨯
Adam W. Cheely,

Affiliation Division of Medicinal Chemistry and Natural Products, Center for Integrated Chemical Biology and Drug Discovery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
⨯
Lewis C. Cantley,

Affiliations Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America, Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Xiaodong Wang,

Affiliation Division of Medicinal Chemistry and Natural Products, Center for Integrated Chemical Biology and Drug Discovery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
⨯
Dmitri Kireev,

Affiliation Division of Medicinal Chemistry and Natural Products, Center for Integrated Chemical Biology and Drug Discovery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
⨯
Albert S. Baldwin,

Affiliations Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, North Carolina, United States of America, Department of Biology, UNC at Chapel Hill, Chapel Hill, North Carolina, United States of America
⨯
William P. Janzen

* E-mail: bjanzen@email.unc.edu

Affiliations Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, North Carolina, United States of America, Division of Medicinal Chemistry and Natural Products, Center for Integrated Chemical Biology and Drug Discovery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
⨯

Development of a High-Throughput Assay for Identifying Inhibitors of TBK1 and IKKε

Jessica E. Hutti,
Melissa A. Porter,
Adam W. Cheely,
Lewis C. Cantley,
Xiaodong Wang,
Dmitri Kireev,
Albert S. Baldwin,
William P. Janzen

Published: July 30, 2012
https://doi.org/10.1371/journal.pone.0041494

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Library screening
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In vitro kinase assay
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