Genome-Wide Histone Acetylation Is Altered in a Transgenic Mouse Model of Huntington's Disease

Karen N. McFarland; Sudeshna Das; Ting Ting Sun; Dmitri Leyfer; Eva Xia; Gavin R. Sangrey; Alexandre Kuhn; Ruth Luthi-Carter; Timothy W. Clark; Ghazaleh Sadri-Vakili; Jang-Ho J. Cha

doi:10.1371/journal.pone.0041423

Loading metrics

Open Access

Peer-reviewed

Research Article

Genome-Wide Histone Acetylation Is Altered in a Transgenic Mouse Model of Huntington's Disease

Karen N. McFarland,

Current address: Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida, United States of America

Affiliation Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Sudeshna Das,

Affiliation MIND Informatics, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Cambridge, Massachusetts, United States of America
⨯
Ting Ting Sun,

Affiliation Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Dmitri Leyfer,

Current address: The Broad Institute, Cambridge, Massachusetts, United States of America

Affiliation MIND Informatics, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Cambridge, Massachusetts, United States of America
⨯
Eva Xia,

Affiliation Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Gavin R. Sangrey,

Affiliation Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Alexandre Kuhn,

Affiliation Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
⨯
Ruth Luthi-Carter,

Affiliation Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
⨯
Timothy W. Clark,

Affiliation MIND Informatics, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Cambridge, Massachusetts, United States of America
⨯
Ghazaleh Sadri-Vakili,

Affiliation Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Jang-Ho J. Cha

* E-mail: j.cha@merck.com

Affiliation Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯

Genome-Wide Histone Acetylation Is Altered in a Transgenic Mouse Model of Huntington's Disease

Karen N. McFarland,
Sudeshna Das,
Ting Ting Sun,
Dmitri Leyfer,
Eva Xia,
Gavin R. Sangrey,
Alexandre Kuhn,
Ruth Luthi-Carter,
Timothy W. Clark,
Ghazaleh Sadri-Vakili

Published: July 27, 2012
https://doi.org/10.1371/journal.pone.0041423

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Histones
Is the Subject Area "Histones" applicable to this article?

Thanks for your feedback.
Acetylation
Is the Subject Area "Acetylation" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Neostriatum
Is the Subject Area "Neostriatum" applicable to this article?

Thanks for your feedback.
Genetic loci
Is the Subject Area "Genetic loci" applicable to this article?

Thanks for your feedback.
DNA transcription
Is the Subject Area "DNA transcription" applicable to this article?

Thanks for your feedback.
Microarrays
Is the Subject Area "Microarrays" applicable to this article?

Thanks for your feedback.
Huntington disease
Is the Subject Area "Huntington disease" applicable to this article?

Thanks for your feedback.