The T Box Transcription Factor TBX2 Promotes Epithelial-Mesenchymal Transition and Invasion of Normal and Malignant Breast Epithelial Cells

Bin Wang; Linsey E. Lindley; Virneliz Fernandez-Vega; Megan E. Rieger; Andrew H. Sims; Karoline J. Briegel

doi:10.1371/journal.pone.0041355

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Peer-reviewed

Research Article

The T Box Transcription Factor TBX2 Promotes Epithelial-Mesenchymal Transition and Invasion of Normal and Malignant Breast Epithelial Cells

Bin Wang ,

Contributed equally to this work with: Bin Wang, Linsey E. Lindley

Affiliation Department of Biochemistry and Molecular Biology, Braman Family Breast Cancer Institute, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
Linsey E. Lindley ,

Contributed equally to this work with: Bin Wang, Linsey E. Lindley

Affiliation Department of Biochemistry and Molecular Biology, Braman Family Breast Cancer Institute, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
Virneliz Fernandez-Vega,

Current address: The Scripps Research Institute, Jupiter, Florida, United States of America

Affiliation Department of Biochemistry and Molecular Biology, Braman Family Breast Cancer Institute, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
Megan E. Rieger,

Current address: Will Rogers Institute Pulmonary Research Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

Affiliation Department of Biochemistry and Molecular Biology, Braman Family Breast Cancer Institute, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
Andrew H. Sims,

Affiliation Applied Bioinformatics of Cancer Research Group, Breakthrough Research Unit, Edinburgh Cancer Research Centre, Edinburgh, United Kingdom
⨯
Karoline J. Briegel

* E-mail: kbriegel@med.miami.edu

Affiliation Department of Biochemistry and Molecular Biology, Braman Family Breast Cancer Institute, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯

The T Box Transcription Factor TBX2 Promotes Epithelial-Mesenchymal Transition and Invasion of Normal and Malignant Breast Epithelial Cells

Bin Wang,
Linsey E. Lindley,
Virneliz Fernandez-Vega,
Megan E. Rieger,
Andrew H. Sims,
Karoline J. Briegel

Published: July 23, 2012
https://doi.org/10.1371/journal.pone.0041355

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Breast cancer
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Breast tumors
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Epithelial cells
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Gene expression
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Transcription factors
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