Silencing SOX2 Induced Mesenchymal-Epithelial Transition and Its Expression Predicts Liver and Lymph Node Metastasis of CRC Patients

Xu Han; Xuefeng Fang; Xiaoyan Lou; Dasong Hua; Wenchao Ding; Gregory Foltz; Leroy Hood; Ying Yuan; Biaoyang Lin

doi:10.1371/journal.pone.0041335

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Peer-reviewed

Research Article

Silencing SOX2 Induced Mesenchymal-Epithelial Transition and Its Expression Predicts Liver and Lymph Node Metastasis of CRC Patients

Xu Han,

Affiliation Systems Biology Division, Zhejiang–California International Nanosystems Institute, Zhejiang University, Hangzhou, Zhejiang, China
⨯
Xuefeng Fang,

Affiliation Department of Medical Oncology, The 2nd Hospital of Zhejiang University Medical College, Hangzhou, Zhejiang, China
⨯
Xiaoyan Lou,

Affiliation Systems Biology Division, Zhejiang–California International Nanosystems Institute, Zhejiang University, Hangzhou, Zhejiang, China
⨯
Dasong Hua,

Affiliation Systems Biology Division, Zhejiang–California International Nanosystems Institute, Zhejiang University, Hangzhou, Zhejiang, China
⨯
Wenchao Ding,

Affiliation Systems Biology Division, Zhejiang–California International Nanosystems Institute, Zhejiang University, Hangzhou, Zhejiang, China
⨯
Gregory Foltz,

Affiliation Swedish Neuroscience Institute, Swedish Medical Center, Seattle, Washington, United States of America
⨯
Leroy Hood,

Affiliation The Institute for Systems Biology, Seattle, Washington, United States of America
⨯
Ying Yuan ,

* E-mail: yuanying1999@zju.edu.cn (YY); biaoylin@gmail.com (BL)

Affiliation Department of Medical Oncology, The 2nd Hospital of Zhejiang University Medical College, Hangzhou, Zhejiang, China
⨯
Biaoyang Lin

* E-mail: yuanying1999@zju.edu.cn (YY); biaoylin@gmail.com (BL)

Affiliations Systems Biology Division, Zhejiang–California International Nanosystems Institute, Zhejiang University, Hangzhou, Zhejiang, China, Swedish Neuroscience Institute, Swedish Medical Center, Seattle, Washington, United States of America, Department of Urology, University of Washington, Seattle, Washington, United States of America
⨯

Silencing SOX2 Induced Mesenchymal-Epithelial Transition and Its Expression Predicts Liver and Lymph Node Metastasis of CRC Patients

Xu Han,
Xuefeng Fang,
Xiaoyan Lou,
Dasong Hua,
Wenchao Ding,
Gregory Foltz,
Leroy Hood,
Ying Yuan,
Biaoyang Lin

Published: August 17, 2012
https://doi.org/10.1371/journal.pone.0041335

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