Activation of Soluble Adenylyl Cyclase Protects against Secretagogue Stimulated Zymogen Activation in Rat Pancreaic Acinar Cells

Thomas R. Kolodecik; Christine A. Shugrue; Edwin C. Thrower; Lonny R. Levin; Jochen Buck; Fred S. Gorelick

doi:10.1371/journal.pone.0041320

Loading metrics

Open Access

Peer-reviewed

Research Article

Activation of Soluble Adenylyl Cyclase Protects against Secretagogue Stimulated Zymogen Activation in Rat Pancreaic Acinar Cells

Thomas R. Kolodecik,

Affiliations Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Veterans Administration Connecticut Healthcare, West Haven, Connecticut, United States of America
⨯
Christine A. Shugrue,

Affiliations Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Veterans Administration Connecticut Healthcare, West Haven, Connecticut, United States of America
⨯
Edwin C. Thrower,

Affiliations Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Veterans Administration Connecticut Healthcare, West Haven, Connecticut, United States of America
⨯
Lonny R. Levin,

Affiliation Department of Pharmacology, Weill Medical College of Cornell University, New York, New York, United States of America
⨯
Jochen Buck,

Affiliation Department of Pharmacology, Weill Medical College of Cornell University, New York, New York, United States of America
⨯
Fred S. Gorelick

* E-mail: fred.gorelick@yale.edu

Affiliations Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut, United States of America, Veterans Administration Connecticut Healthcare, West Haven, Connecticut, United States of America
⨯

Activation of Soluble Adenylyl Cyclase Protects against Secretagogue Stimulated Zymogen Activation in Rat Pancreaic Acinar Cells

Thomas R. Kolodecik,
Christine A. Shugrue,
Edwin C. Thrower,
Lonny R. Levin,
Jochen Buck,
Fred S. Gorelick

Published: July 23, 2012
https://doi.org/10.1371/journal.pone.0041320

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Bicarbonates
Is the Subject Area "Bicarbonates" applicable to this article?

Thanks for your feedback.
Zymogens
Is the Subject Area "Zymogens" applicable to this article?

Thanks for your feedback.
Secretion
Is the Subject Area "Secretion" applicable to this article?

Thanks for your feedback.
Pancreatitis
Is the Subject Area "Pancreatitis" applicable to this article?

Thanks for your feedback.
Immunoblotting
Is the Subject Area "Immunoblotting" applicable to this article?

Thanks for your feedback.
Polymerase chain reaction
Is the Subject Area "Polymerase chain reaction" applicable to this article?

Thanks for your feedback.
Pancreas
Is the Subject Area "Pancreas" applicable to this article?

Thanks for your feedback.
Vacuoles
Is the Subject Area "Vacuoles" applicable to this article?

Thanks for your feedback.