Glucopyranosyl Lipid Adjuvant (GLA), a Synthetic TLR4 Agonist, Promotes Potent Systemic and Mucosal Responses to Intranasal Immunization with HIVgp140

Open Access

Peer-reviewed

Research Article

Mauricio A. Arias,

Affiliation Centre for Infection and Immunity, St. George’s University of London, London, United Kingdom
⨯
Griet A. Van Roey,

Affiliation Centre for Infection and Immunity, St. George’s University of London, London, United Kingdom
⨯
John S. Tregoning,

Affiliations Centre for Infection and Immunity, St. George’s University of London, London, United Kingdom, Mucosal Infection and Immunity, Section of Infectious Diseases, Imperial College London, London, United Kingdom
⨯
Magdalini Moutaftsi,

Affiliation Infectious Diseases Research Institute (IDRI), Seattle, Washington, United States of America
⨯
Rhea N. Coler,

Affiliation Infectious Diseases Research Institute (IDRI), Seattle, Washington, United States of America
⨯
Hillarie P. Windish,

Affiliation Infectious Diseases Research Institute (IDRI), Seattle, Washington, United States of America
⨯
Steven G. Reed,

Affiliation Infectious Diseases Research Institute (IDRI), Seattle, Washington, United States of America
⨯
Darrick Carter,

Affiliation Infectious Diseases Research Institute (IDRI), Seattle, Washington, United States of America
⨯
Robin J. Shattock

* E-mail: r.shattock@imperial.ac.uk

Affiliations Centre for Infection and Immunity, St. George’s University of London, London, United Kingdom, Mucosal Infection and Immunity, Section of Infectious Diseases, Imperial College London, London, United Kingdom
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Immunologic adjuvants
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Immune response
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Antibodies
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T cells
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Enzyme-linked immunoassays
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HIV
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Humoral immune response
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