Structural Origins for the Loss of Catalytic Activities of Bifunctional Human LTA4H Revealed through Molecular Dynamics Simulations

Sundarapandian Thangapandian; Shalini John; Prettina Lazar; Sun Choi; Keun Woo Lee

doi:10.1371/journal.pone.0041063

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Open Access

Peer-reviewed

Research Article

Structural Origins for the Loss of Catalytic Activities of Bifunctional Human LTA4H Revealed through Molecular Dynamics Simulations

Sundarapandian Thangapandian,

Affiliations Division of Applied Life Science (BK21 Program), Systems and Synthetic Agrobiotech Center, Plant Molecular Biology and Biotechnology Research Center, Research Institute of Natural Science, Gyeongsang National University, Jinju, Republic of Korea, College of Pharmacy, Division of Life and Pharmaceutical Sciences and National Core Research Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul, Republic of Korea
⨯
Shalini John,

Affiliation Division of Applied Life Science (BK21 Program), Systems and Synthetic Agrobiotech Center, Plant Molecular Biology and Biotechnology Research Center, Research Institute of Natural Science, Gyeongsang National University, Jinju, Republic of Korea
⨯
Prettina Lazar,

Affiliation Division of Applied Life Science (BK21 Program), Systems and Synthetic Agrobiotech Center, Plant Molecular Biology and Biotechnology Research Center, Research Institute of Natural Science, Gyeongsang National University, Jinju, Republic of Korea
⨯
Sun Choi,

Affiliation College of Pharmacy, Division of Life and Pharmaceutical Sciences and National Core Research Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul, Republic of Korea
⨯
Keun Woo Lee

* E-mail: kwlee@gnu.ac.kr

Affiliation Division of Applied Life Science (BK21 Program), Systems and Synthetic Agrobiotech Center, Plant Molecular Biology and Biotechnology Research Center, Research Institute of Natural Science, Gyeongsang National University, Jinju, Republic of Korea
⨯

Structural Origins for the Loss of Catalytic Activities of Bifunctional Human LTA4H Revealed through Molecular Dynamics Simulations

Sundarapandian Thangapandian,
Shalini John,
Prettina Lazar,
Sun Choi,
Keun Woo Lee

Published: July 25, 2012
https://doi.org/10.1371/journal.pone.0041063

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