Loss of Activating EGFR Mutant Gene Contributes to Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer Cells

• Keisuke Tabara ,

  Contributed equally to this work with: Keisuke Tabara, Rina Kanda, Kahori Sonoda

  Affiliation Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan

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• Rina Kanda ,

  Contributed equally to this work with: Keisuke Tabara, Rina Kanda, Kahori Sonoda

  Affiliation Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan

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• Kahori Sonoda ,

  Contributed equally to this work with: Keisuke Tabara, Rina Kanda, Kahori Sonoda

  Affiliation Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan

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• Takuya Kubo,

  Affiliation Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan

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• Yuichi Murakami,

  Affiliations Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan, St. Mary’s Hospital, Kurume, Japan

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• Akihiko Kawahara,

  Affiliation Department of Diagnostic Pathology, Kurume University Hospital, Kurume, Japan

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• Koichi Azuma,

  Affiliation Division of Respirology, Neurology and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan

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• Hideyuki Abe,

  Affiliation Department of Diagnostic Pathology, Kurume University Hospital, Kurume, Japan

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• Masayoshi Kage,

  Affiliation Department of Diagnostic Pathology, Kurume University Hospital, Kurume, Japan

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• Aki Yoshinaga,

  Affiliation Division of Genome Analysis, Research Center for Genetic Information, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan

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• Tomoko Tahira,

  Affiliation Division of Genome Analysis, Research Center for Genetic Information, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan

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• Kenshi Hayashi,

  Affiliation Division of Genome Analysis, Research Center for Genetic Information, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan

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• Tokuzo Arao,

  Affiliation Department of Genome Biology, Faculty of Medicine, Kinki University, Osaka, Japan

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• Kazuto Nishio,

  Affiliation Department of Genome Biology, Faculty of Medicine, Kinki University, Osaka, Japan

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• Rafael Rosell,

  Affiliations Catalan Institute of Oncology, Hospital Germans Trias i Pujol, Badalona, Spain, Pangaea Biotech, S.L., USP Dexeus University Institute Barcelona, Barcelona, Spain

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• Michihiko Kuwano,

  Affiliation Laboratory of Molecular Cancer Biology, Department of Clinical Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan

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•  [ ... ],
• Mayumi Ono

  * E-mail: mono@phar.kyushu-u.ac.jp

  Affiliation Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan

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