Recombinant Lipidated HPV E7 Induces a Th-1-Biased Immune Response and Protective Immunity against Cervical Cancer in a Mouse Model

Chiung-Yi Huang; Jeremy J. W. Chen; Kuan-Yin Shen; Li-Sheng Chang; Yi-Chen Yeh; I-Hua Chen; Pele Chong; Shih-Jen Liu; Chih-Hsiang Leng

doi:10.1371/journal.pone.0040970

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Open Access

Peer-reviewed

Research Article

Recombinant Lipidated HPV E7 Induces a Th-1-Biased Immune Response and Protective Immunity against Cervical Cancer in a Mouse Model

Chiung-Yi Huang ,

Contributed equally to this work with: Chiung-Yi Huang, Jeremy J. W. Chen

Affiliations National Institute of Infectious Disease and Vaccinology, National Health Research Institutes, Zhunan Town, Miaoli, Taiwan, Republic of China, Institute of Molecular Biology, National Chung Hsing University, Taichung, Taiwan, Republic of China
⨯
Jeremy J. W. Chen ,

Contributed equally to this work with: Chiung-Yi Huang, Jeremy J. W. Chen

Affiliation Institute of Molecular Biology, National Chung Hsing University, Taichung, Taiwan, Republic of China
⨯
Kuan-Yin Shen,

Affiliation National Institute of Infectious Disease and Vaccinology, National Health Research Institutes, Zhunan Town, Miaoli, Taiwan, Republic of China
⨯
Li-Sheng Chang,

Affiliation National Institute of Infectious Disease and Vaccinology, National Health Research Institutes, Zhunan Town, Miaoli, Taiwan, Republic of China
⨯
Yi-Chen Yeh,

Affiliation National Institute of Infectious Disease and Vaccinology, National Health Research Institutes, Zhunan Town, Miaoli, Taiwan, Republic of China
⨯
I-Hua Chen,

Affiliation National Institute of Infectious Disease and Vaccinology, National Health Research Institutes, Zhunan Town, Miaoli, Taiwan, Republic of China
⨯
Pele Chong,

Affiliation National Institute of Infectious Disease and Vaccinology, National Health Research Institutes, Zhunan Town, Miaoli, Taiwan, Republic of China
⨯
Shih-Jen Liu ,

* E-mail: levent@nhri.org.tw (S-JL); leoleng@nhri.org.tw (C-HL)

Affiliations National Institute of Infectious Disease and Vaccinology, National Health Research Institutes, Zhunan Town, Miaoli, Taiwan, Republic of China, Graduate Institute of Immunology, China Medical University, Taichung, Taiwan, Republic of China
⨯
Chih-Hsiang Leng

* E-mail: levent@nhri.org.tw (S-JL); leoleng@nhri.org.tw (C-HL)

Affiliations National Institute of Infectious Disease and Vaccinology, National Health Research Institutes, Zhunan Town, Miaoli, Taiwan, Republic of China, Graduate Institute of Immunology, China Medical University, Taichung, Taiwan, Republic of China
⨯

Recombinant Lipidated HPV E7 Induces a Th-1-Biased Immune Response and Protective Immunity against Cervical Cancer in a Mouse Model

Chiung-Yi Huang,
Jeremy J. W. Chen,
Kuan-Yin Shen,
Li-Sheng Chang,
Yi-Chen Yeh,
I-Hua Chen,
Pele Chong,
Shih-Jen Liu,
Chih-Hsiang Leng

Published: July 18, 2012
https://doi.org/10.1371/journal.pone.0040970

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