ATRA Inhibits the Proliferation of DU145 Prostate Cancer Cells through Reducing the Methylation Level of HOXB13 Gene

Zhiwei Liu; Guoling Ren; Chenyan Shangguan; Lijing Guo; Zhixiong Dong; Yueyang Li; Weina Zhang; Li Zhao; Pingfu Hou; Yu Zhang; Xiuli Wang; Jun Lu; Baiqu Huang

doi:10.1371/journal.pone.0040943

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Open Access

Peer-reviewed

Research Article

ATRA Inhibits the Proliferation of DU145 Prostate Cancer Cells through Reducing the Methylation Level of HOXB13 Gene

Zhiwei Liu ,

Contributed equally to this work with: Zhiwei Liu, Guoling Ren

Affiliation The Institute of Genetics and Cytology, Northeast Normal University, Changchun, China
⨯
Guoling Ren ,

Contributed equally to this work with: Zhiwei Liu, Guoling Ren

Affiliation College of Life Sciences, Daqing Normal University, Daqing, Heilongjiang, China
⨯
Chenyan Shangguan,

Affiliation The Institute of Genetics and Cytology, Northeast Normal University, Changchun, China
⨯
Lijing Guo,

Affiliation The Institute of Genetics and Cytology, Northeast Normal University, Changchun, China
⨯
Zhixiong Dong,

Affiliation The College of Life Science, Tianjin Normal University, Tianjin, China
⨯
Yueyang Li,

Affiliation The Institute of Genetics and Cytology, Northeast Normal University, Changchun, China
⨯
Weina Zhang,

Affiliation The Key Laboratory of Molecular Epigenetics of Ministry of Education, Northeast Normal University, Changchun, China
⨯
Li Zhao,

Affiliation The Key Laboratory of Molecular Epigenetics of Ministry of Education, Northeast Normal University, Changchun, China
⨯
Pingfu Hou,

Affiliation The Key Laboratory of Molecular Epigenetics of Ministry of Education, Northeast Normal University, Changchun, China
⨯
Yu Zhang,

Affiliation The Institute of Genetics and Cytology, Northeast Normal University, Changchun, China
⨯
Xiuli Wang,

Affiliation The Institute of Genetics and Cytology, Northeast Normal University, Changchun, China
⨯
Jun Lu ,

* E-mail: huangbq705@nenu.edu.cn (BQH); ycsuo@nenu.edu.cn (JL)

Affiliation The Key Laboratory of Molecular Epigenetics of Ministry of Education, Northeast Normal University, Changchun, China
⨯
Baiqu Huang

* E-mail: huangbq705@nenu.edu.cn (BQH); ycsuo@nenu.edu.cn (JL)

Affiliation The Institute of Genetics and Cytology, Northeast Normal University, Changchun, China
⨯

ATRA Inhibits the Proliferation of DU145 Prostate Cancer Cells through Reducing the Methylation Level of HOXB13 Gene

Zhiwei Liu,
Guoling Ren,
Chenyan Shangguan,
Lijing Guo,
Zhixiong Dong,
Yueyang Li,
Weina Zhang,
Li Zhao,
Pingfu Hou,
Yu Zhang

Published: July 13, 2012
https://doi.org/10.1371/journal.pone.0040943

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DU145 cells
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DNA methylation
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