Oxygen Glucose Deprivation in Rat Hippocampal Slice Cultures Results in Alterations in Carnitine Homeostasis and Mitochondrial Dysfunction

Thomas F. Rau; Qing Lu; Shruti Sharma; Xutong Sun; Gregory Leary; Matthew L. Beckman; Yali Hou; Mark S. Wainwright; Michael Kavanaugh; David J. Poulsen; Stephen M. Black

doi:10.1371/journal.pone.0040881

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Research Article

Oxygen Glucose Deprivation in Rat Hippocampal Slice Cultures Results in Alterations in Carnitine Homeostasis and Mitochondrial Dysfunction

Thomas F. Rau,

Affiliation Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana, United States of America
⨯
Qing Lu,

Affiliation Vascular Biology Center, Medical College of Georgia, Augusta, Georgia, United States of America
⨯
Shruti Sharma,

Affiliation Vascular Biology Center, Medical College of Georgia, Augusta, Georgia, United States of America
⨯
Xutong Sun,

Affiliation Vascular Biology Center, Medical College of Georgia, Augusta, Georgia, United States of America
⨯
Gregory Leary,

Affiliation Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana, United States of America
⨯
Matthew L. Beckman,

Affiliation Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana, United States of America
⨯
Yali Hou,

Affiliation Vascular Biology Center, Medical College of Georgia, Augusta, Georgia, United States of America
⨯
Mark S. Wainwright,

Affiliation Department of Pediatrics, Northwestern University Feinberg School of Medicine, Children's Memorial Hospital, 2300 Children's Plaza, Chicago, Illinois, United States of America
⨯
Michael Kavanaugh,

Affiliation Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana, United States of America
⨯
David J. Poulsen ,

* E-mail: sblack@georgiahealth.edu (SMB); david.poulsen@umontana.edu (DJP)

Affiliation Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana, United States of America
⨯
Stephen M. Black

* E-mail: sblack@georgiahealth.edu (SMB); david.poulsen@umontana.edu (DJP)

Affiliation Vascular Biology Center, Medical College of Georgia, Augusta, Georgia, United States of America
⨯

Oxygen Glucose Deprivation in Rat Hippocampal Slice Cultures Results in Alterations in Carnitine Homeostasis and Mitochondrial Dysfunction

Thomas F. Rau,
Qing Lu,
Shruti Sharma,
Xutong Sun,
Gregory Leary,
Matthew L. Beckman,
Yali Hou,
Mark S. Wainwright,
Michael Kavanaugh,
David J. Poulsen

Published: September 11, 2012
https://doi.org/10.1371/journal.pone.0040881

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Mitochondria
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Hippocampus
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Fluorescence imaging
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Neuronal death
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Oxygen
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Mitochondrial membrane
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Glucose
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