The Effect of Vorinostat on the Development of Resistance to Doxorubicin in Neuroblastoma

Timothy B. Lautz; Chunfa Jie; Sandra Clark; Jessica A. Naiditch; Nadereh Jafari; Yi-Yong Qiu; Xin Zheng; Fei Chu; Mary Beth Madonna

doi:10.1371/journal.pone.0040816

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Peer-reviewed

Research Article

The Effect of Vorinostat on the Development of Resistance to Doxorubicin in Neuroblastoma

Timothy B. Lautz,

Affiliations Department of Surgery, Lurie Children’s Hospital, Northwestern University, Chicago, Illinois, United States of America, Cancer Biology Program, Children’s Memorial Research Center, Northwestern University, Chicago, Illinois, United States of America
⨯
Chunfa Jie,

Affiliation Center for Genetic Medicine, Northwestern University, Chicago, Illinois, United States of America
⨯
Sandra Clark,

Affiliation Cancer Biology Program, Children’s Memorial Research Center, Northwestern University, Chicago, Illinois, United States of America
⨯
Jessica A. Naiditch,

Affiliations Department of Surgery, Lurie Children’s Hospital, Northwestern University, Chicago, Illinois, United States of America, Cancer Biology Program, Children’s Memorial Research Center, Northwestern University, Chicago, Illinois, United States of America
⨯
Nadereh Jafari,

Affiliation Center for Genetic Medicine, Northwestern University, Chicago, Illinois, United States of America
⨯
Yi-Yong Qiu,

Affiliation Cancer Biology Program, Children’s Memorial Research Center, Northwestern University, Chicago, Illinois, United States of America
⨯
Xin Zheng,

Affiliation Cancer Biology Program, Children’s Memorial Research Center, Northwestern University, Chicago, Illinois, United States of America
⨯
Fei Chu ,

* E-mail: mmadonna@childrensmemorial.org (MBM); fchu@childrensmemorial.org (FC)

Affiliation Cancer Biology Program, Children’s Memorial Research Center, Northwestern University, Chicago, Illinois, United States of America
⨯
Mary Beth Madonna

* E-mail: mmadonna@childrensmemorial.org (MBM); fchu@childrensmemorial.org (FC)

Affiliations Department of Surgery, Lurie Children’s Hospital, Northwestern University, Chicago, Illinois, United States of America, Cancer Biology Program, Children’s Memorial Research Center, Northwestern University, Chicago, Illinois, United States of America
⨯

The Effect of Vorinostat on the Development of Resistance to Doxorubicin in Neuroblastoma

Timothy B. Lautz,
Chunfa Jie,
Sandra Clark,
Jessica A. Naiditch,
Nadereh Jafari,
Yi-Yong Qiu,
Xin Zheng,
Fei Chu,
Mary Beth Madonna

Published: July 19, 2012
https://doi.org/10.1371/journal.pone.0040816

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Gene expression
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Metabolic processes
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Neuroblastoma
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Gene regulation
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Somatostatin
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Neuroblastoma cells
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