Toll-Like Receptor (TLR) 2 and TLR4 Differentially Regulate Doxorubicin Induced Cardiomyopathy in Mice

Yonggang Ma; Xiaowei Zhang; Huayan Bao; Su Mi; Wenfeng Cai; Huimin Yan; Qingqing Wang; Ziyan Wang; Jun Yan; Guochang Fan; Merry L. Lindsey; Zhuowei Hu

doi:10.1371/journal.pone.0040763

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Peer-reviewed

Research Article

Toll-Like Receptor (TLR) 2 and TLR4 Differentially Regulate Doxorubicin Induced Cardiomyopathy in Mice

Yonggang Ma ,

Contributed equally to this work with: Yonggang Ma, Xiaowei Zhang

Affiliations Molecular Immunology and Pharmacology Group, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China, San Antonio Cardiovascular Proteomics Center, Barshop Institute of Longevity and Aging Studies, and Division of Geriatrics, Gerontology and Palliative Medicine, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Xiaowei Zhang ,

Contributed equally to this work with: Yonggang Ma, Xiaowei Zhang

Affiliation Molecular Immunology and Pharmacology Group, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China
⨯
Huayan Bao,

Affiliation Molecular Immunology and Pharmacology Group, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China
⨯
Su Mi,

Affiliation Molecular Immunology and Pharmacology Group, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China
⨯
Wenfeng Cai,

Affiliation Molecular Immunology and Pharmacology Group, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China
⨯
Huimin Yan,

Affiliation Molecular Immunology and Pharmacology Group, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China
⨯
Qingqing Wang,

Affiliation Molecular Immunology and Pharmacology Group, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China
⨯
Ziyan Wang,

Affiliation Molecular Immunology and Pharmacology Group, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China
⨯
Jun Yan,

Affiliation Molecular Immunology and Pharmacology Group, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China
⨯
Guochang Fan,

Affiliation Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
⨯
Merry L. Lindsey,

Affiliation San Antonio Cardiovascular Proteomics Center, Barshop Institute of Longevity and Aging Studies, and Division of Geriatrics, Gerontology and Palliative Medicine, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Zhuowei Hu

* E-mail: huzhuowei@imm.ac.cn

Affiliation Molecular Immunology and Pharmacology Group, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China
⨯

Toll-Like Receptor (TLR) 2 and TLR4 Differentially Regulate Doxorubicin Induced Cardiomyopathy in Mice

Yonggang Ma,
Xiaowei Zhang,
Huayan Bao,
Su Mi,
Wenfeng Cai,
Huimin Yan,
Qingqing Wang,
Ziyan Wang,
Jun Yan,
Guochang Fan

Published: July 13, 2012
https://doi.org/10.1371/journal.pone.0040763

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Toll-like receptors
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Inflammation
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Cardiomyopathies
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Fibrosis
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Autophagic cell death
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Immune receptor signaling
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Cardiovascular physiology
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Mouse models
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