Localization and Sub-Cellular Shuttling of HTLV-1 Tax with the miRNA Machinery

Rachel Van Duyne; Irene Guendel; Zachary Klase; Aarthi Narayanan; William Coley; Elizabeth Jaworski; Jessica Roman; Anastas Popratiloff; Renaud Mahieux; Kylene Kehn-Hall; Fatah Kashanchi

doi:10.1371/journal.pone.0040662

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Open Access

Peer-reviewed

Research Article

Localization and Sub-Cellular Shuttling of HTLV-1 Tax with the miRNA Machinery

Rachel Van Duyne,

Affiliations Department of Molecular and Microbiology, National Center for Biodefense & Infectious Diseases, George Mason University, Manassas, Virginia, United States of America, Department of Microbiology, Immunology, & Tropical Medicine, The George Washington University Medical Center, Washington, D.C., United States of America
⨯
Irene Guendel,

Affiliation Department of Molecular and Microbiology, National Center for Biodefense & Infectious Diseases, George Mason University, Manassas, Virginia, United States of America
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Zachary Klase,

Affiliation Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Aarthi Narayanan,

Affiliation Department of Molecular and Microbiology, National Center for Biodefense & Infectious Diseases, George Mason University, Manassas, Virginia, United States of America
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William Coley,

Affiliation Department of Microbiology, Immunology, & Tropical Medicine, The George Washington University Medical Center, Washington, D.C., United States of America
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Elizabeth Jaworski,

Affiliation Department of Molecular and Microbiology, National Center for Biodefense & Infectious Diseases, George Mason University, Manassas, Virginia, United States of America
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Jessica Roman,

Affiliation Department of Molecular and Microbiology, National Center for Biodefense & Infectious Diseases, George Mason University, Manassas, Virginia, United States of America
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Anastas Popratiloff,

Affiliation Department of Anatomy and Regenerative Biology, The George Washington University, Washington, D.C., United States of America
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Renaud Mahieux,

Affiliation Retroviral Oncogenesis Team, INSERM-U758 Virologie Humaine, Lyon, France
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Kylene Kehn-Hall,

Affiliation Department of Molecular and Microbiology, National Center for Biodefense & Infectious Diseases, George Mason University, Manassas, Virginia, United States of America
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Fatah Kashanchi

* E-mail: fkashanc@gmu.edu

Affiliations Department of Molecular and Microbiology, National Center for Biodefense & Infectious Diseases, George Mason University, Manassas, Virginia, United States of America, Department of Microbiology, Immunology, & Tropical Medicine, The George Washington University Medical Center, Washington, D.C., United States of America
⨯

Localization and Sub-Cellular Shuttling of HTLV-1 Tax with the miRNA Machinery

Rachel Van Duyne,
Irene Guendel,
Zachary Klase,
Aarthi Narayanan,
William Coley,
Elizabeth Jaworski,
Jessica Roman,
Anastas Popratiloff,
Renaud Mahieux,
Kylene Kehn-Hall

Published: July 10, 2012
https://doi.org/10.1371/journal.pone.0040662

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HTLV-1
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MicroRNAs
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Transfection
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RNA interference
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293T cells
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Transcription factors
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Proteasome inhibitors
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Viral replication
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