Deletion of the Innate Immune NLRP3 Receptor Abolishes Cardiac Ischemic Preconditioning and Is Associated with Decreased Il-6/STAT3 Signaling

• Coert J. Zuurbier ,

  Contributed equally to this work with: Coert J. Zuurbier, Willeke M. C. Jong

  * E-mail: c.j.zuurbier@amc.uva.nl

  Affiliation Laboratory of Experimental Intensive Care and Anesthesiology, Department of Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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• Willeke M. C. Jong ,

  Contributed equally to this work with: Coert J. Zuurbier, Willeke M. C. Jong

  Affiliation Laboratory of Experimental Intensive Care and Anesthesiology, Department of Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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• Otto Eerbeek,

  Affiliation Department of Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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• Anneke Koeman,

  Affiliation Laboratory of Experimental Intensive Care and Anesthesiology, Department of Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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• Wilco P. Pulskens,

  Affiliation Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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• Loes M. Butter,

  Affiliation Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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• Jaklien C. Leemans,

  Affiliation Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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• Markus W. Hollmann

  Affiliation Laboratory of Experimental Intensive Care and Anesthesiology, Department of Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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