Ectopically Expressed Perforin-1 Is Proapoptotic in Tumor Cell Lines by Increasing Caspase-3 Activity and the Nuclear Translocation of Cytochrome c

• Li-Feng Wang ,

  Contributed equally to this work with: Li-Feng Wang, Fang Wang, Jun-Tang Li

  Affiliation State Key Laboratory of Cancer Biology, Departments of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fourth Military Medical University, Xi’an, China

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• Fang Wang ,

  Contributed equally to this work with: Li-Feng Wang, Fang Wang, Jun-Tang Li

  Affiliation Department of Microbiology, School of Basic Medical Sciences, Fourth Military Medical University, Xi’an, China

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• Jun-Tang Li ,

  Contributed equally to this work with: Li-Feng Wang, Fang Wang, Jun-Tang Li

  Affiliation Department of Immunology, School of Basic Medical Sciences, Fourth Military Medical University, Xi’an, China

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• Wei-Hong Wen,

  Affiliation Department of Immunology, School of Basic Medical Sciences, Fourth Military Medical University, Xi’an, China

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• Jing Zhao,

  Affiliation State Key Laboratory of Cancer Biology, Departments of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fourth Military Medical University, Xi’an, China

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• Lin-Tao Jia,

  Affiliation State Key Laboratory of Cancer Biology, Departments of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fourth Military Medical University, Xi’an, China

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• Yan-Ling Meng,

  Affiliation Department of Immunology, School of Basic Medical Sciences, Fourth Military Medical University, Xi’an, China

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• Yun-Xin Cao,

  Affiliation Department of Immunology, School of Basic Medical Sciences, Fourth Military Medical University, Xi’an, China

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• Li-Bo Yao,

  Affiliation State Key Laboratory of Cancer Biology, Departments of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fourth Military Medical University, Xi’an, China

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• Si-Yi Chen,

  Affiliation Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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• Yan-Ming Xu ,

  * E-mail: agyang@fmmu.edu.cn (A-GY); amyymxu@stu.edu.cn (Y-MX)

  Affiliation Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, China

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• An-Gang Yang

  * E-mail: agyang@fmmu.edu.cn (A-GY); amyymxu@stu.edu.cn (Y-MX)

  Affiliation Department of Immunology, School of Basic Medical Sciences, Fourth Military Medical University, Xi’an, China

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