Pharmacological Inhibition of Microsomal Prostaglandin E Synthase-1 Suppresses Epidermal Growth Factor Receptor-Mediated Tumor Growth and Angiogenesis

Federica Finetti; Erika Terzuoli; Elena Bocci; Isabella Coletta; Lorenzo Polenzani; Giorgina Mangano; Maria Alessandra Alisi; Nicola Cazzolla; Antonio Giachetti; Marina Ziche; Sandra Donnini

doi:10.1371/journal.pone.0040576

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Peer-reviewed

Research Article

Pharmacological Inhibition of Microsomal Prostaglandin E Synthase-1 Suppresses Epidermal Growth Factor Receptor-Mediated Tumor Growth and Angiogenesis

Federica Finetti ,

Contributed equally to this work with: Federica Finetti, Erika Terzuoli

Affiliation Department of Biotechnology, University of Siena, Via Aldo Moro, 2, Siena, and Istituto Toscano Tumori (ITT), Italy
⨯
Erika Terzuoli ,

Contributed equally to this work with: Federica Finetti, Erika Terzuoli

Affiliation Department of Biotechnology, University of Siena, Via Aldo Moro, 2, Siena, and Istituto Toscano Tumori (ITT), Italy
⨯
Elena Bocci,

Affiliation Department of Biotechnology, University of Siena, Via Aldo Moro, 2, Siena, and Istituto Toscano Tumori (ITT), Italy
⨯
Isabella Coletta,

Affiliation Angelini Research Center–A.C.R.A.F. S.p.A., Piazzale della stazione, S. Palomba-Pomezia (Rome), Italy
⨯
Lorenzo Polenzani,

Affiliation Angelini Research Center–A.C.R.A.F. S.p.A., Piazzale della stazione, S. Palomba-Pomezia (Rome), Italy
⨯
Giorgina Mangano,

Affiliation Angelini Research Center–A.C.R.A.F. S.p.A., Piazzale della stazione, S. Palomba-Pomezia (Rome), Italy
⨯
Maria Alessandra Alisi,

Affiliation Angelini Research Center–A.C.R.A.F. S.p.A., Piazzale della stazione, S. Palomba-Pomezia (Rome), Italy
⨯
Nicola Cazzolla,

Affiliation Angelini Research Center–A.C.R.A.F. S.p.A., Piazzale della stazione, S. Palomba-Pomezia (Rome), Italy
⨯
Antonio Giachetti,

Affiliation Department of Biotechnology, University of Siena, Via Aldo Moro, 2, Siena, and Istituto Toscano Tumori (ITT), Italy
⨯
Marina Ziche ,

* E-mail: marina.ziche@unisi.it (MZ); sandra.donnini@unisi.it (SD)

Affiliation Department of Biotechnology, University of Siena, Via Aldo Moro, 2, Siena, and Istituto Toscano Tumori (ITT), Italy
⨯
Sandra Donnini

* E-mail: marina.ziche@unisi.it (MZ); sandra.donnini@unisi.it (SD)

Affiliation Department of Biotechnology, University of Siena, Via Aldo Moro, 2, Siena, and Istituto Toscano Tumori (ITT), Italy
⨯

Pharmacological Inhibition of Microsomal Prostaglandin E Synthase-1 Suppresses Epidermal Growth Factor Receptor-Mediated Tumor Growth and Angiogenesis

Federica Finetti,
Erika Terzuoli,
Elena Bocci,
Isabella Coletta,
Lorenzo Polenzani,
Giorgina Mangano,
Maria Alessandra Alisi,
Nicola Cazzolla,
Antonio Giachetti,
Marina Ziche

Published: July 18, 2012
https://doi.org/10.1371/journal.pone.0040576

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