GM-CSF Priming Drives Bone Marrow-Derived Macrophages to a Pro-Inflammatory Pattern and Downmodulates PGE2 in Response to TLR2 Ligands

Carlos Arterio Sorgi; Stephanie Rose; Nathalie Court; Daniela Carlos; Francisco Wanderley Garcia Paula-Silva; Patricia Aparecida Assis; Fabiani Gai Frantz; Bernhard Ryffel; Valerie Quesniaux; Lúcia Helena Faccioli

doi:10.1371/journal.pone.0040523

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Open Access

Peer-reviewed

Research Article

GM-CSF Priming Drives Bone Marrow-Derived Macrophages to a Pro-Inflammatory Pattern and Downmodulates PGE₂ in Response to TLR2 Ligands

Carlos Arterio Sorgi,

Affiliation Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto – Universidade de São Paulo – Ribeirão Preto, SP – Brazil
⨯
Stephanie Rose,

Affiliations CNRS, UMR6218, Orleans, France, Orleans University, Molecular Immunology and Embryology, Orleans, France
⨯
Nathalie Court,

Affiliations CNRS, UMR6218, Orleans, France, Orleans University, Molecular Immunology and Embryology, Orleans, France
⨯
Daniela Carlos,

Affiliation Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto – Universidade de São Paulo – Ribeirão Preto, SP – Brazil
⨯
Francisco Wanderley Garcia Paula-Silva,

Affiliation Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto – Universidade de São Paulo – Ribeirão Preto, SP – Brazil
⨯
Patricia Aparecida Assis,

Affiliation Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto – Universidade de São Paulo – Ribeirão Preto, SP – Brazil
⨯
Fabiani Gai Frantz,

Affiliation Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto – Universidade de São Paulo – Ribeirão Preto, SP – Brazil
⨯
Bernhard Ryffel,

Affiliations CNRS, UMR6218, Orleans, France, Orleans University, Molecular Immunology and Embryology, Orleans, France
⨯
Valerie Quesniaux,

Affiliations CNRS, UMR6218, Orleans, France, Orleans University, Molecular Immunology and Embryology, Orleans, France
⨯
Lúcia Helena Faccioli

* E-mail: faccioli@fcfrp.usp.br.

Affiliation Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto – Universidade de São Paulo – Ribeirão Preto, SP – Brazil
⨯

GM-CSF Priming Drives Bone Marrow-Derived Macrophages to a Pro-Inflammatory Pattern and Downmodulates PGE₂ in Response to TLR2 Ligands

Carlos Arterio Sorgi,
Stephanie Rose,
Nathalie Court,
Daniela Carlos,
Francisco Wanderley Garcia Paula-Silva,
Patricia Aparecida Assis,
Fabiani Gai Frantz,
Bernhard Ryffel,
Valerie Quesniaux,
Lúcia Helena Faccioli

Published: July 13, 2012
https://doi.org/10.1371/journal.pone.0040523

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Macrophages
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Toll-like receptors
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Cytokines
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Enzyme-linked immunoassays
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Immune response
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Inflammation
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Lipid mediators
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