Tamoxifen-Induced Epigenetic Silencing of Oestrogen-Regulated Genes in Anti-Hormone Resistant Breast Cancer

Andrew Stone; Fatima Valdés-Mora; Julia M. W. Gee; Lynne Farrow; Richard A. McClelland; Heidi Fiegl; Carol Dutkowski; Rachael A. McCloy; Robert L. Sutherland; Elizabeth A. Musgrove; Robert I. Nicholson

doi:10.1371/journal.pone.0040466

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Open Access

Peer-reviewed

Research Article

Tamoxifen-Induced Epigenetic Silencing of Oestrogen-Regulated Genes in Anti-Hormone Resistant Breast Cancer

Andrew Stone ,

* E-mail: a.stone@garvan.org.au

Affiliations Welsh School of Pharmacy, Redwood Building, Cardiff University, Cardiff, Wales, United Kingdom, The Kinghorn Cancer Centre and Cancer Research Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
⨯
Fatima Valdés-Mora,

Affiliation Department of Epigenetics, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
⨯
Julia M. W. Gee,

Affiliation Welsh School of Pharmacy, Redwood Building, Cardiff University, Cardiff, Wales, United Kingdom
⨯
Lynne Farrow,

Affiliation Welsh School of Pharmacy, Redwood Building, Cardiff University, Cardiff, Wales, United Kingdom
⨯
Richard A. McClelland,

Affiliation Welsh School of Pharmacy, Redwood Building, Cardiff University, Cardiff, Wales, United Kingdom
⨯
Heidi Fiegl,

Affiliation Department of Gynaecology and Obstetrics, Innsbruck Medical University, Innsbruck, Austria
⨯
Carol Dutkowski,

Affiliation Welsh School of Pharmacy, Redwood Building, Cardiff University, Cardiff, Wales, United Kingdom
⨯
Rachael A. McCloy,

Affiliation The Kinghorn Cancer Centre and Cancer Research Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
⨯
Robert L. Sutherland,

Affiliations The Kinghorn Cancer Centre and Cancer Research Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia, St Vincent’s Clinical School, Faculty of Medicine, University of New South Wales, St Vincent’s Hospital, Sydney, New South Wales, Australia
⨯
Elizabeth A. Musgrove,

Affiliations The Kinghorn Cancer Centre and Cancer Research Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia, St Vincent’s Clinical School, Faculty of Medicine, University of New South Wales, St Vincent’s Hospital, Sydney, New South Wales, Australia
⨯
Robert I. Nicholson

Affiliation Welsh School of Pharmacy, Redwood Building, Cardiff University, Cardiff, Wales, United Kingdom
⨯

Tamoxifen-Induced Epigenetic Silencing of Oestrogen-Regulated Genes in Anti-Hormone Resistant Breast Cancer

Andrew Stone,
Fatima Valdés-Mora,
Julia M. W. Gee,
Lynne Farrow,
Richard A. McClelland,
Heidi Fiegl,
Carol Dutkowski,
Rachael A. McCloy,
Robert L. Sutherland,
Elizabeth A. Musgrove

Published: July 10, 2012
https://doi.org/10.1371/journal.pone.0040466

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DNA methylation
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Breast cancer
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Cell proliferation
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