Low Level Sequence Variant Analysis of Recombinant Proteins: An Optimized Approach

Anne Zeck; Jörg Thomas Regula; Vincent Larraillet; Björn Mautz; Oliver Popp; Ulrich Göpfert; Frank Wiegeshoff; Ulrike E. E. Vollertsen; Ingo H. Gorr; Hans Koll; Apollon Papadimitriou

doi:10.1371/journal.pone.0040328

Loading metrics

Open Access

Peer-reviewed

Research Article

Low Level Sequence Variant Analysis of Recombinant Proteins: An Optimized Approach

Anne Zeck ,

* E-mail: anne.zeck@nmi.de

Current address: NMI Natural and Medical Sciences, Institute at the University of Tuebingen, Reutlingen, Germany

Affiliation Biologics Research, Pharma Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany
⨯
Jörg Thomas Regula,

Affiliation Biologics Research, Pharma Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany
⨯
Vincent Larraillet,

Affiliation Biologics Research, Pharma Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany
⨯
Björn Mautz,

Affiliation Biologics Research, Pharma Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany
⨯
Oliver Popp,

Affiliation Biologics Research, Pharma Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany
⨯
Ulrich Göpfert,

Affiliation Biologics Research, Pharma Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany
⨯
Frank Wiegeshoff,

Current address: Abbott GmbH, Ludwigshafen, Germany

Affiliation Biologics Research, Pharma Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany
⨯
Ulrike E. E. Vollertsen,

Affiliation Biologics Research, Pharma Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany
⨯
Ingo H. Gorr,

Affiliation Biologics Research, Pharma Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany
⨯
Hans Koll,

Affiliation Biologics Research, Pharma Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany
⨯
Apollon Papadimitriou

Affiliation Biologics Research, Pharma Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany
⨯

Low Level Sequence Variant Analysis of Recombinant Proteins: An Optimized Approach

Anne Zeck,
Jörg Thomas Regula,
Vincent Larraillet,
Björn Mautz,
Oliver Popp,
Ulrich Göpfert,
Frank Wiegeshoff,
Ulrike E. E. Vollertsen,
Ingo H. Gorr,
Hans Koll

Published: July 6, 2012
https://doi.org/10.1371/journal.pone.0040328

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Phenylalanine
Is the Subject Area "Phenylalanine" applicable to this article?

Thanks for your feedback.
Fermentation
Is the Subject Area "Fermentation" applicable to this article?

Thanks for your feedback.
Point mutation
Is the Subject Area "Point mutation" applicable to this article?

Thanks for your feedback.
Amino acid substitution
Is the Subject Area "Amino acid substitution" applicable to this article?

Thanks for your feedback.
Amino acid analysis
Is the Subject Area "Amino acid analysis" applicable to this article?

Thanks for your feedback.
DNA sequencing
Is the Subject Area "DNA sequencing" applicable to this article?

Thanks for your feedback.
Amino acid sequence analysis
Is the Subject Area "Amino acid sequence analysis" applicable to this article?

Thanks for your feedback.
Recombinant proteins
Is the Subject Area "Recombinant proteins" applicable to this article?

Thanks for your feedback.