Maximum Diastolic Potential of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Depends Critically on IKr

Michael Xavier Doss; José M. Di Diego; Robert J. Goodrow; Yuesheng Wu; Jonathan M. Cordeiro; Vladislav V. Nesterenko; Héctor Barajas-Martínez; Dan Hu; Janire Urrutia; Mayurika Desai; Jacqueline A. Treat; Agapios Sachinidis; Charles Antzelevitch

doi:10.1371/journal.pone.0040288

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Open Access

Peer-reviewed

Research Article

Maximum Diastolic Potential of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Depends Critically on I_Kr

Michael Xavier Doss ,

Contributed equally to this work with: Michael Xavier Doss, José M. Di Diego

Affiliation Stem Cell Research and Genomics, Masonic Medical Research Laboratory, Utica, New York, United States of America
⨯
José M. Di Diego ,

Contributed equally to this work with: Michael Xavier Doss, José M. Di Diego

* E-mail: ca@mmrl.edu (CA); didiego@mmrl.edu(JMDD)

Affiliation Experimental Cardiology, Masonic Medical Research Laboratory, Utica, New York, United States of America
⨯
Robert J. Goodrow,

Affiliation Experimental Cardiology, Masonic Medical Research Laboratory, Utica, New York, United States of America
⨯
Yuesheng Wu,

Affiliation Stem Cell Research and Genomics, Masonic Medical Research Laboratory, Utica, New York, United States of America
⨯
Jonathan M. Cordeiro,

Affiliation Experimental Cardiology, Masonic Medical Research Laboratory, Utica, New York, United States of America
⨯
Vladislav V. Nesterenko,

Affiliation Stem Cell Research and Genomics, Masonic Medical Research Laboratory, Utica, New York, United States of America
⨯
Héctor Barajas-Martínez,

Affiliation Stem Cell Research and Genomics, Masonic Medical Research Laboratory, Utica, New York, United States of America
⨯
Dan Hu,

Affiliation Stem Cell Research and Genomics, Masonic Medical Research Laboratory, Utica, New York, United States of America
⨯
Janire Urrutia,

Affiliation Stem Cell Research and Genomics, Masonic Medical Research Laboratory, Utica, New York, United States of America
⨯
Mayurika Desai,

Affiliation Stem Cell Research and Genomics, Masonic Medical Research Laboratory, Utica, New York, United States of America
⨯
Jacqueline A. Treat,

Affiliation Stem Cell Research and Genomics, Masonic Medical Research Laboratory, Utica, New York, United States of America
⨯
Agapios Sachinidis,

Affiliation Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, Cologne, Germany
⨯
Charles Antzelevitch

* E-mail: ca@mmrl.edu (CA); didiego@mmrl.edu(JMDD)

Affiliation Experimental Cardiology, Masonic Medical Research Laboratory, Utica, New York, United States of America
⨯

Maximum Diastolic Potential of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Depends Critically on I_Kr

Michael Xavier Doss,
José M. Di Diego,
Robert J. Goodrow,
Yuesheng Wu,
Jonathan M. Cordeiro,
Vladislav V. Nesterenko,
Héctor Barajas-Martínez,
Dan Hu,
Janire Urrutia,
Mayurika Desai

Published: July 5, 2012
https://doi.org/10.1371/journal.pone.0040288

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