A Pro-Cathepsin L Mutant Is a Luminal Substrate for Endoplasmic-Reticulum-Associated Degradation in C. elegans

Mark T. Miedel; Nathan J. Graf; Kate E. Stephen; Olivia S. Long; Stephen C. Pak; David H. Perlmutter; Gary A. Silverman; Cliff J. Luke

doi:10.1371/journal.pone.0040145

Loading metrics

Open Access

Peer-reviewed

Research Article

A Pro-Cathepsin L Mutant Is a Luminal Substrate for Endoplasmic-Reticulum-Associated Degradation in C. elegans

Mark T. Miedel,

Affiliation Department of Pediatrics, Cell Biology and Physiology, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh of UPMC and Magee-Womens Hospital of UPMC, Pittsburgh, Pennsylvania, United States of America
⨯
Nathan J. Graf,

Affiliation Department of Pediatrics, Cell Biology and Physiology, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh of UPMC and Magee-Womens Hospital of UPMC, Pittsburgh, Pennsylvania, United States of America
⨯
Kate E. Stephen,

Affiliation Department of Pediatrics, Cell Biology and Physiology, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh of UPMC and Magee-Womens Hospital of UPMC, Pittsburgh, Pennsylvania, United States of America
⨯
Olivia S. Long,

Affiliation Department of Pediatrics, Cell Biology and Physiology, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh of UPMC and Magee-Womens Hospital of UPMC, Pittsburgh, Pennsylvania, United States of America
⨯
Stephen C. Pak,

Affiliation Department of Pediatrics, Cell Biology and Physiology, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh of UPMC and Magee-Womens Hospital of UPMC, Pittsburgh, Pennsylvania, United States of America
⨯
David H. Perlmutter,

Affiliation Department of Pediatrics, Cell Biology and Physiology, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh of UPMC and Magee-Womens Hospital of UPMC, Pittsburgh, Pennsylvania, United States of America
⨯
Gary A. Silverman,

Affiliation Department of Pediatrics, Cell Biology and Physiology, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh of UPMC and Magee-Womens Hospital of UPMC, Pittsburgh, Pennsylvania, United States of America
⨯
Cliff J. Luke

* E-mail: cliff.luke@chp.edu

Affiliation Department of Pediatrics, Cell Biology and Physiology, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh of UPMC and Magee-Womens Hospital of UPMC, Pittsburgh, Pennsylvania, United States of America
⨯

A Pro-Cathepsin L Mutant Is a Luminal Substrate for Endoplasmic-Reticulum-Associated Degradation in C. elegans

Mark T. Miedel,
Nathan J. Graf,
Kate E. Stephen,
Olivia S. Long,
Stephen C. Pak,
David H. Perlmutter,
Gary A. Silverman,
Cliff J. Luke

Published: July 2, 2012
https://doi.org/10.1371/journal.pone.0040145

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

RNA interference
Is the Subject Area "RNA interference" applicable to this article?

Thanks for your feedback.
Genetically modified animals
Is the Subject Area "Genetically modified animals" applicable to this article?

Thanks for your feedback.
Caenorhabditis elegans
Is the Subject Area "Caenorhabditis elegans" applicable to this article?

Thanks for your feedback.
Gastrointestinal tract
Is the Subject Area "Gastrointestinal tract" applicable to this article?

Thanks for your feedback.
Yellow fluorescent protein
Is the Subject Area "Yellow fluorescent protein" applicable to this article?

Thanks for your feedback.
Autophagic cell death
Is the Subject Area "Autophagic cell death" applicable to this article?

Thanks for your feedback.
Yeast
Is the Subject Area "Yeast" applicable to this article?

Thanks for your feedback.
Lysosomes
Is the Subject Area "Lysosomes" applicable to this article?

Thanks for your feedback.