Ganglioside GM3 Has an Essential Role in the Pathogenesis and Progression of Rheumatoid Arthritis

Yukinori Tsukuda; Norimasa Iwasaki; Naoki Seito; Masashi Kanayama; Naoki Fujitani; Yasuro Shinohara; Yasuhiko Kasahara; Tomohiro Onodera; Koji Suzuki; Tsuyoshi Asano; Akio Minami; Tadashi Yamashita

doi:10.1371/journal.pone.0040136

Loading metrics

Open Access

Peer-reviewed

Research Article

Ganglioside GM3 Has an Essential Role in the Pathogenesis and Progression of Rheumatoid Arthritis

Yukinori Tsukuda,

Affiliation Department of Orthopaedic Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
⨯
Norimasa Iwasaki ,

* E-mail: ty11106@sci.hokudai.ac.jp (TY); niwasaki@med.hokudai.ac.jp (NI)

Affiliation Department of Orthopaedic Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
⨯
Naoki Seito,

Affiliation Department of Orthopaedic Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
⨯
Masashi Kanayama,

Affiliation Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
⨯
Naoki Fujitani,

Affiliation Laboratory of Medical and Functional Glycomics, Graduate School of Advanced Life Science, Hokkaido University, Sapporo, Japan
⨯
Yasuro Shinohara,

Affiliation Laboratory of Medical and Functional Glycomics, Graduate School of Advanced Life Science, Hokkaido University, Sapporo, Japan
⨯
Yasuhiko Kasahara,

Affiliation Department of Orthopaedic Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
⨯
Tomohiro Onodera,

Affiliation Department of Orthopaedic Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
⨯
Koji Suzuki,

Affiliation Hokkaido Orthopaedic Memorial Hospital, Sapporo, Japan
⨯
Tsuyoshi Asano,

Affiliation Department of Orthopaedic Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
⨯
Akio Minami,

Affiliation Department of Orthopaedic Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
⨯
Tadashi Yamashita

* E-mail: ty11106@sci.hokudai.ac.jp (TY); niwasaki@med.hokudai.ac.jp (NI)

Affiliations Faculty of Advanced Life Science, Frontier Research Center for Post-Genomic Science and Technology, Hokkaido University, Sapporo, Japan, World Class University Program, Kyungpook National University School of Medicine, Daegu, Korea
⨯

Ganglioside GM3 Has an Essential Role in the Pathogenesis and Progression of Rheumatoid Arthritis

Yukinori Tsukuda,
Norimasa Iwasaki,
Naoki Seito,
Masashi Kanayama,
Naoki Fujitani,
Yasuro Shinohara,
Yasuhiko Kasahara,
Tomohiro Onodera,
Koji Suzuki,
Tsuyoshi Asano

Published: June 29, 2012
https://doi.org/10.1371/journal.pone.0040136

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Sphingolipids
Is the Subject Area "Sphingolipids" applicable to this article?

Thanks for your feedback.
T cells
Is the Subject Area "T cells" applicable to this article?

Thanks for your feedback.
Rheumatoid arthritis
Is the Subject Area "Rheumatoid arthritis" applicable to this article?

Thanks for your feedback.
Arthritis
Is the Subject Area "Arthritis" applicable to this article?

Thanks for your feedback.
Pathogenesis
Is the Subject Area "Pathogenesis" applicable to this article?

Thanks for your feedback.
Antibodies
Is the Subject Area "Antibodies" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Enzyme-linked immunoassays
Is the Subject Area "Enzyme-linked immunoassays" applicable to this article?

Thanks for your feedback.