Cardiac Kallikrein-Kinin System Is Upregulated in Chronic Volume Overload and Mediates an Inflammatory Induced Collagen Loss

Chih-Chang Wei; Yuanwen Chen; Lindsay C. Powell; Junying Zheng; Ke Shi; Wayne E. Bradley; Pamela C. Powell; Sarfaraz Ahmad; Carlos M. Ferrario; Louis J. Dell’Italia

doi:10.1371/journal.pone.0040110

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Open Access

Peer-reviewed

Research Article

Cardiac Kallikrein-Kinin System Is Upregulated in Chronic Volume Overload and Mediates an Inflammatory Induced Collagen Loss

Chih-Chang Wei ,

* E-mail: chih@uab.edu

Affiliations Birmingham Veteran Affairs Medical Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Yuanwen Chen,

Affiliation Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
⨯
Lindsay C. Powell,

Affiliation Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Junying Zheng,

Affiliation Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Ke Shi,

Affiliation Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Wayne E. Bradley,

Affiliation Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Pamela C. Powell,

Affiliation Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Sarfaraz Ahmad,

Affiliation Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America
⨯
Carlos M. Ferrario,

Affiliation Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America
⨯
Louis J. Dell’Italia

Affiliations Birmingham Veteran Affairs Medical Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯

Cardiac Kallikrein-Kinin System Is Upregulated in Chronic Volume Overload and Mediates an Inflammatory Induced Collagen Loss

Chih-Chang Wei,
Yuanwen Chen,
Lindsay C. Powell,
Junying Zheng,
Ke Shi,
Wayne E. Bradley,
Pamela C. Powell,
Sarfaraz Ahmad,
Carlos M. Ferrario,
Louis J. Dell’Italia

Published: June 29, 2012
https://doi.org/10.1371/journal.pone.0040110

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