Gq/11-Mediated Signaling and Hypertrophy in Mice with Cardiac-Specific Transgenic Expression of Regulator of G-Protein Signaling 2

Cindy Park-Windhol; Peng Zhang; Ming Zhu; Jialin Su; Leonard Chaves Jr; Angel E. Maldonado; Michelle E. King; Lisa Rickey; Darragh Cullen; Ulrike Mende

doi:10.1371/journal.pone.0040048

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Peer-reviewed

Research Article

Gq/11-Mediated Signaling and Hypertrophy in Mice with Cardiac-Specific Transgenic Expression of Regulator of G-Protein Signaling 2

Cindy Park-Windhol,

Affiliations Cardiology Division, Cardiovascular Research Center, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island, United States of America, Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island, United States of America
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Peng Zhang,

Affiliation Cardiology Division, Cardiovascular Research Center, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
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Ming Zhu,

Affiliation Cardiology Division, Cardiovascular Research Center, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
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Jialin Su,

Affiliation Cardiology Division, Cardiovascular Research Center, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
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Leonard Chaves Jr,

Affiliation Cardiology Division, Cardiovascular Research Center, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
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Angel E. Maldonado,

Affiliation Cardiology Division, Cardiovascular Research Center, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
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Michelle E. King,

Affiliation Cardiology Division, Cardiovascular Research Center, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
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Lisa Rickey,

Affiliations Cardiology Division, Cardiovascular Research Center, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island, United States of America, Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island, United States of America
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Darragh Cullen,

Affiliation Cardiac Muscle Research Laboratory, Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
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Ulrike Mende

* E-mail: ulrike_mende@brown.edu

Affiliation Cardiology Division, Cardiovascular Research Center, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
⨯

Gq/11-Mediated Signaling and Hypertrophy in Mice with Cardiac-Specific Transgenic Expression of Regulator of G-Protein Signaling 2

Cindy Park-Windhol,
Peng Zhang,
Ming Zhu,
Jialin Su,
Leonard Chaves Jr,
Angel E. Maldonado,
Michelle E. King,
Lisa Rickey,
Darragh Cullen,
Ulrike Mende

Published: July 3, 2012
https://doi.org/10.1371/journal.pone.0040048

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Genetically modified animals
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Mouse models
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Cardiac ventricles
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Signal inhibition
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Cardiac atria
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G-protein signaling
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Muscle cells
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Hyperexpression techniques
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