MMP-8 Deficiency Increases TLR/RAGE Ligands S100A8 and S100A9 and Exacerbates Lung Inflammation during Endotoxemia

Adrián González-López; Alina Aguirre; Inés López-Alonso; Laura Amado; Aurora Astudillo; María Soledad Fernández-García; María F. Suárez; Estefanía Batalla-Solís; Enrique Colado; Guillermo M. Albaiceta

doi:10.1371/journal.pone.0039940

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Peer-reviewed

Research Article

MMP-8 Deficiency Increases TLR/RAGE Ligands S100A8 and S100A9 and Exacerbates Lung Inflammation during Endotoxemia

Adrián González-López,

Affiliation Departamento de Biología Funcional, Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, Oviedo, Spain
⨯
Alina Aguirre,

Affiliation Departamento de Biología Funcional, Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, Oviedo, Spain
⨯
Inés López-Alonso,

Affiliation Departamento de Biología Funcional, Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, Oviedo, Spain
⨯
Laura Amado,

Affiliation Servicio de Medicina Intensiva, Hospital Universitario Central de Asturias, Oviedo, Spain
⨯
Aurora Astudillo,

Affiliation Servicio de Anatomía Patológica, Hospital Universitario Central de Asturias, Oviedo, Spain
⨯
María Soledad Fernández-García,

Affiliation Servicio de Anatomía Patológica, Hospital Universitario Central de Asturias, Oviedo, Spain
⨯
María F. Suárez,

Affiliation Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, Oviedo, Spain
⨯
Estefanía Batalla-Solís,

Affiliations Departamento de Biología Funcional, Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, Oviedo, Spain, Servicio de Medicina Intensiva, Hospital Universitario Central de Asturias, Oviedo, Spain
⨯
Enrique Colado,

Affiliation Servicio de Hematología y Hemoterapia, Hospital Universitario Central de Asturias, Oviedo, Spain
⨯
Guillermo M. Albaiceta

* E-mail: Guillermo.muniz@sespa.princast.es

Affiliations Departamento de Biología Funcional, Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, Oviedo, Spain, Servicio de Medicina Intensiva, Hospital Universitario Central de Asturias, Oviedo, Spain, CIBER-Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
⨯

MMP-8 Deficiency Increases TLR/RAGE Ligands S100A8 and S100A9 and Exacerbates Lung Inflammation during Endotoxemia

Adrián González-López,
Alina Aguirre,
Inés López-Alonso,
Laura Amado,
Aurora Astudillo,
María Soledad Fernández-García,
María F. Suárez,
Estefanía Batalla-Solís,
Enrique Colado,
Guillermo M. Albaiceta

Published: June 29, 2012
https://doi.org/10.1371/journal.pone.0039940

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