Valsartan Improves Adipose Tissue Function in Humans with Impaired Glucose Metabolism: A Randomized Placebo-Controlled Double-Blind Trial

Gijs H. Goossens; Chantalle C. M. Moors; Nynke J. van der Zijl; Nicolas Venteclef; Rohia Alili; Johan W. E. Jocken; Yvonne Essers; Jack P. Cleutjens; Karine Clément; Michaela Diamant; Ellen E. Blaak

doi:10.1371/journal.pone.0039930

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Open Access

Peer-reviewed

Research Article

Valsartan Improves Adipose Tissue Function in Humans with Impaired Glucose Metabolism: A Randomized Placebo-Controlled Double-Blind Trial

Gijs H. Goossens ,

* E-mail: G.Goossens@maastrichtuniversity.nl

Affiliation Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Chantalle C. M. Moors,

Affiliation Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Nynke J. van der Zijl,

Affiliation Diabetes Center, Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
⨯
Nicolas Venteclef,

Affiliation INSERM, Nutriomique U872 (Eq 7), University Pierre et Marie Curie-Paris 6, Cordelier Research Center, Human Nutrition Research Center; Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière hospital, Paris, France
⨯
Rohia Alili,

Affiliation INSERM, Nutriomique U872 (Eq 7), University Pierre et Marie Curie-Paris 6, Cordelier Research Center, Human Nutrition Research Center; Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière hospital, Paris, France
⨯
Johan W. E. Jocken,

Affiliation Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Yvonne Essers,

Affiliation Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Jack P. Cleutjens,

Affiliation Department of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Karine Clément,

Affiliation INSERM, Nutriomique U872 (Eq 7), University Pierre et Marie Curie-Paris 6, Cordelier Research Center, Human Nutrition Research Center; Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière hospital, Paris, France
⨯
Michaela Diamant,

Affiliation Diabetes Center, Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
⨯
Ellen E. Blaak

Affiliation Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands
⨯

Valsartan Improves Adipose Tissue Function in Humans with Impaired Glucose Metabolism: A Randomized Placebo-Controlled Double-Blind Trial

Gijs H. Goossens,
Chantalle C. M. Moors,
Nynke J. van der Zijl,
Nicolas Venteclef,
Rohia Alili,
Johan W. E. Jocken,
Yvonne Essers,
Jack P. Cleutjens,
Karine Clément,
Michaela Diamant

Published: June 29, 2012
https://doi.org/10.1371/journal.pone.0039930

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Adipocytes
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Insulin
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Gene expression
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Adipose tissue
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