Intrathecal Injection of Spironolactone Attenuates Radicular Pain by Inhibition of Spinal Microglia Activation in a Rat Model

Yu-e Sun; Liangyu Peng; Xiaofeng Sun; Jinhua Bo; Dong Yang; Yaguo Zheng; Chenglong Liu; Beibei Zhu; Zhengliang Ma; Xiaoping Gu

doi:10.1371/journal.pone.0039897

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Open Access

Peer-reviewed

Research Article

Intrathecal Injection of Spironolactone Attenuates Radicular Pain by Inhibition of Spinal Microglia Activation in a Rat Model

Yu-e Sun ,

Contributed equally to this work with: Yu-e Sun, Liangyu Peng

Affiliation Department of Anaesthesiology, Affiliated Drum-Tower Hospital of Medical College of Nanjing University, Nanjing, Jiangsu province, China
⨯
Liangyu Peng ,

Contributed equally to this work with: Yu-e Sun, Liangyu Peng

Affiliation Department of Anaesthesiology, Affiliated Drum-Tower Hospital of Medical College of Nanjing University, Nanjing, Jiangsu province, China
⨯
Xiaofeng Sun,

Affiliation Department of Anaesthesiology, Affiliated Drum-Tower Hospital of Medical College of Nanjing University, Nanjing, Jiangsu province, China
⨯
Jinhua Bo,

Affiliation Department of Anaesthesiology, Affiliated Drum-Tower Hospital of Medical College of Nanjing University, Nanjing, Jiangsu province, China
⨯
Dong Yang,

Affiliation Department of Anaesthesiology, Affiliated Drum-Tower Hospital of Medical College of Nanjing University, Nanjing, Jiangsu province, China
⨯
Yaguo Zheng,

Affiliation Department of Anaesthesiology, Affiliated Drum-Tower Hospital of Medical College of Nanjing University, Nanjing, Jiangsu province, China
⨯
Chenglong Liu,

Affiliation Department of Anaesthesiology, Affiliated Drum-Tower Hospital of Medical College of Nanjing University, Nanjing, Jiangsu province, China
⨯
Beibei Zhu,

Affiliation Department of Anaesthesiology, Affiliated Drum-Tower Hospital of Medical College of Nanjing University, Nanjing, Jiangsu province, China
⨯
Zhengliang Ma ,

* E-mail: mazhengliang1964@yahoo.com.cn (ZLM); xiaopinggu1@gmail.com (XPG)

Affiliation Department of Anaesthesiology, Affiliated Drum-Tower Hospital of Medical College of Nanjing University, Nanjing, Jiangsu province, China
⨯
Xiaoping Gu

* E-mail: mazhengliang1964@yahoo.com.cn (ZLM); xiaopinggu1@gmail.com (XPG)

Affiliation Department of Anaesthesiology, Affiliated Drum-Tower Hospital of Medical College of Nanjing University, Nanjing, Jiangsu province, China
⨯

Intrathecal Injection of Spironolactone Attenuates Radicular Pain by Inhibition of Spinal Microglia Activation in a Rat Model

Yu-e Sun,
Liangyu Peng,
Xiaofeng Sun,
Jinhua Bo,
Dong Yang,
Yaguo Zheng,
Chenglong Liu,
Beibei Zhu,
Zhengliang Ma,
Xiaoping Gu

Published: June 29, 2012
https://doi.org/10.1371/journal.pone.0039897

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