A Novel SND1-BRAF Fusion Confers Resistance to c-Met Inhibitor PF-04217903 in GTL16 Cells though MAPK Activation

Nathan V. Lee; Maruja E. Lira; Adam Pavlicek; Jingjing Ye; Dana Buckman; Shubha Bagrodia; Sreesha P. Srinivasa; Yongjun Zhao; Samuel Aparicio; Paul A. Rejto; James G. Christensen; Keith A. Ching

doi:10.1371/journal.pone.0039653

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Open Access

Peer-reviewed

Research Article

A Novel SND1-BRAF Fusion Confers Resistance to c-Met Inhibitor PF-04217903 in GTL16 Cells though MAPK Activation

Nathan V. Lee,

Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America
⨯
Maruja E. Lira,

Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America
⨯
Adam Pavlicek,

Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America
⨯
Jingjing Ye,

Current address: Division of Biostatistics, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland, United States of America

Affiliation Global Pre-Clinical Statistics, Pfizer Global Research & Development, San Diego, California, United States of America
⨯
Dana Buckman,

Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America
⨯
Shubha Bagrodia,

Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America
⨯
Sreesha P. Srinivasa,

Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America
⨯
Yongjun Zhao,

Affiliation Michael Smith Genome Sciences Centre, BC Cancer Research Centre, Vancouver, British Columbia, Canada
⨯
Samuel Aparicio,

Affiliations Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada, Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
⨯
Paul A. Rejto,

Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America
⨯
James G. Christensen,

Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America
⨯
Keith A. Ching

* E-mail: keith.ching@pfizer.com

Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America
⨯

A Novel SND1-BRAF Fusion Confers Resistance to c-Met Inhibitor PF-04217903 in GTL16 Cells though MAPK Activation

Nathan V. Lee,
Maruja E. Lira,
Adam Pavlicek,
Jingjing Ye,
Dana Buckman,
Shubha Bagrodia,
Sreesha P. Srinivasa,
Yongjun Zhao,
Samuel Aparicio,
Paul A. Rejto

Published: June 22, 2012
https://doi.org/10.1371/journal.pone.0039653

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21 Sep 2013
01:14 GMT
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TCGA Reference Posted by killerz on 21 Sep 2013 at 01:14 GMT
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13 Aug 2012
18:40 GMT
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SLC45A3 Posted by killerz on 13 Aug 2012 at 18:40 GMT
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22 Jun 2012
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Sequence coordinate correction Posted by killerz on 22 Jun 2012 at 21:57 GMT

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