Blocking Fibroblast Growth Factor Receptor Signaling Inhibits Tumor Growth, Lymphangiogenesis, and Metastasis

Frédéric Larrieu-Lahargue; Alana L. Welm; Marion Bouchecareilh; Kari Alitalo; Dean Y. Li; Andreas Bikfalvi; Patrick Auguste

doi:10.1371/journal.pone.0039540

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Peer-reviewed

Research Article

Blocking Fibroblast Growth Factor Receptor Signaling Inhibits Tumor Growth, Lymphangiogenesis, and Metastasis

Frédéric Larrieu-Lahargue,

Current address: INSERM U1034, Pessac, France

Affiliations Laboratoire de l’Angiogenèse et du Microenvironement des Cancers, Université de Bordeaux, Talence, France, INSERM U 1029, Talence, France, Program in Molecular Medicine, University of Utah, Salt Lake City, Utah, United States of America
⨯
Alana L. Welm,

Affiliation Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, United States of America
⨯
Marion Bouchecareilh,

Affiliations Laboratoire de l’Angiogenèse et du Microenvironement des Cancers, Université de Bordeaux, Talence, France, INSERM U 1029, Talence, France
⨯
Kari Alitalo,

Affiliation Molecular Cancer Biology Program, Biomedicum Helsinki, Department of Pathology, Haartman Institute and Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
⨯
Dean Y. Li ,

* E-mail: a.bikfalvi@angio.u-bordeaux1.fr (AB); dean.li@hmbg.utah.edu (DYL)

Affiliations Program in Molecular Medicine, University of Utah, Salt Lake City, Utah, United States of America, Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, United States of America
⨯
Andreas Bikfalvi ,

* E-mail: a.bikfalvi@angio.u-bordeaux1.fr (AB); dean.li@hmbg.utah.edu (DYL)

Affiliations Laboratoire de l’Angiogenèse et du Microenvironement des Cancers, Université de Bordeaux, Talence, France, INSERM U 1029, Talence, France
⨯
Patrick Auguste

Affiliations Laboratoire de l’Angiogenèse et du Microenvironement des Cancers, Université de Bordeaux, Talence, France, INSERM U 1029, Talence, France
⨯

Blocking Fibroblast Growth Factor Receptor Signaling Inhibits Tumor Growth, Lymphangiogenesis, and Metastasis

Frédéric Larrieu-Lahargue,
Alana L. Welm,
Marion Bouchecareilh,
Kari Alitalo,
Dean Y. Li,
Andreas Bikfalvi,
Patrick Auguste

Published: June 25, 2012
https://doi.org/10.1371/journal.pone.0039540

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Lung and intrathoracic tumors
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VEGF signaling
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Breast cancer
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Signal inhibition
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Endothelial cells
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Cancers and neoplasms
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