Antagonism of miR-21 Reverses Epithelial-Mesenchymal Transition and Cancer Stem Cell Phenotype through AKT/ERK1/2 Inactivation by Targeting PTEN

Mingli Han; Manran Liu; Yimeng Wang; Xin Chen; Jianli Xu; Yan Sun; Liuyang Zhao; Hongbo Qu; Yuanming Fan; Chengyi Wu

doi:10.1371/journal.pone.0039520

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Open Access

Peer-reviewed

Research Article

Antagonism of miR-21 Reverses Epithelial-Mesenchymal Transition and Cancer Stem Cell Phenotype through AKT/ERK1/2 Inactivation by Targeting PTEN

Mingli Han,

Affiliations Department of Endocrine Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China, The Key Laboratory of Laboratory Medical Diagnostics in the Ministry of Education and Department of Clinical Biochemistry, Chongqing Medical University, Chongqing, China
⨯
Manran Liu,

Affiliation The Key Laboratory of Laboratory Medical Diagnostics in the Ministry of Education and Department of Clinical Biochemistry, Chongqing Medical University, Chongqing, China
⨯
Yimeng Wang,

Affiliation Department of Emergency, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
⨯
Xin Chen,

Affiliation Department of Endocrine Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
⨯
Jianli Xu,

Affiliation Department of General Surgery, The People’s Hospital of Jiangjin City, Chongqing, China
⨯
Yan Sun,

Affiliation The Key Laboratory of Laboratory Medical Diagnostics in the Ministry of Education and Department of Clinical Biochemistry, Chongqing Medical University, Chongqing, China
⨯
Liuyang Zhao,

Affiliation The Key Laboratory of Laboratory Medical Diagnostics in the Ministry of Education and Department of Clinical Biochemistry, Chongqing Medical University, Chongqing, China
⨯
Hongbo Qu,

Affiliation Department of Endocrine Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
⨯
Yuanming Fan,

Affiliation Department of Endocrine Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
⨯
Chengyi Wu

* E-mail: wuchengyi1192@163.com

Affiliation Department of Endocrine Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
⨯

Antagonism of miR-21 Reverses Epithelial-Mesenchymal Transition and Cancer Stem Cell Phenotype through AKT/ERK1/2 Inactivation by Targeting PTEN

Mingli Han,
Manran Liu,
Yimeng Wang,
Xin Chen,
Jianli Xu,
Yan Sun,
Liuyang Zhao,
Hongbo Qu,
Yuanming Fan,
Chengyi Wu

Published: June 25, 2012
https://doi.org/10.1371/journal.pone.0039520

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