Peripheral SLC6A4 DNA Methylation Is Associated with In Vivo Measures of Human Brain Serotonin Synthesis and Childhood Physical Aggression

Dongsha Wang; Moshe Szyf; Chawki Benkelfat; Nadine Provençal; Gustavo Turecki; Doretta Caramaschi; Sylvana M. Côté; Frank Vitaro; Richard E. Tremblay; Linda Booij

doi:10.1371/journal.pone.0039501

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Peer-reviewed

Research Article

Peripheral SLC6A4 DNA Methylation Is Associated with In Vivo Measures of Human Brain Serotonin Synthesis and Childhood Physical Aggression

Dongsha Wang,

Affiliations Sainte-Justine Hospital Research Center, Montreal, Quebec, Canada, Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada, Sackler Program for Epigenetics and Psychobiology, McGill University, Montreal, Quebec, Canada
⨯
Moshe Szyf ,

* E-mail: linda.booij@umontreal.ca (LB); moshe.szyf@mcgill.ca (MS); tremblar@grip.umontreal.ca (RET)

Affiliations Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada, Sackler Program for Epigenetics and Psychobiology, McGill University, Montreal, Quebec, Canada
⨯
Chawki Benkelfat,

Affiliation Department of Psychiatry, McGill University, Montreal, Quebec, Canada
⨯
Nadine Provençal,

Affiliations Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada, Sackler Program for Epigenetics and Psychobiology, McGill University, Montreal, Quebec, Canada
⨯
Gustavo Turecki,

Affiliation Department of Psychiatry, McGill University, Montreal, Quebec, Canada
⨯
Doretta Caramaschi,

Affiliations Sainte-Justine Hospital Research Center, Montreal, Quebec, Canada, Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
⨯
Sylvana M. Côté,

Affiliation Sainte-Justine Hospital Research Center, Montreal, Quebec, Canada
⨯
Frank Vitaro,

Affiliations Sainte-Justine Hospital Research Center, Montreal, Quebec, Canada, Department of Psycho-Education, University of Montreal, Montreal, Quebec, Canada
⨯
Richard E. Tremblay ,

* E-mail: linda.booij@umontreal.ca (LB); moshe.szyf@mcgill.ca (MS); tremblar@grip.umontreal.ca (RET)

Affiliations Sainte-Justine Hospital Research Center, Montreal, Quebec, Canada, Department of Psychology and Pediatrics, University of Montreal, Montreal, Quebec, Canada, School of Public Health, Psychotherapy and Population Sciences, University College Dublin, Dublin, Ireland
⨯
Linda Booij

* E-mail: linda.booij@umontreal.ca (LB); moshe.szyf@mcgill.ca (MS); tremblar@grip.umontreal.ca (RET)

Affiliations Sainte-Justine Hospital Research Center, Montreal, Quebec, Canada, Department of Psychiatry, McGill University, Montreal, Quebec, Canada, Department of Psychiatry, University of Montreal, Montreal, Quebec, Canada
⨯

Peripheral SLC6A4 DNA Methylation Is Associated with In Vivo Measures of Human Brain Serotonin Synthesis and Childhood Physical Aggression

Dongsha Wang,
Moshe Szyf,
Chawki Benkelfat,
Nadine Provençal,
Gustavo Turecki,
Doretta Caramaschi,
Sylvana M. Côté,
Frank Vitaro,
Richard E. Tremblay,
Linda Booij

Published: June 20, 2012
https://doi.org/10.1371/journal.pone.0039501

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DNA methylation
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Aggression
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Monocytes
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T cells
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Serotonin
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DNA synthesis
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DNA transcription
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Gene expression
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