Down-Regulation of HtrA1 Activates the Epithelial-Mesenchymal Transition and ATM DNA Damage Response Pathways

Ning Wang; Kristin A. Eckert; Ali R. Zomorrodi; Ping Xin; Weihua Pan; Debra A. Shearer; Judith Weisz; Costas D. Maranus; Gary A. Clawson

doi:10.1371/journal.pone.0039446

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Peer-reviewed

Research Article

Down-Regulation of HtrA1 Activates the Epithelial-Mesenchymal Transition and ATM DNA Damage Response Pathways

Ning Wang,

Affiliation Gittlen Cancer Research Institute & Department of Pathology, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania, United States of America
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Kristin A. Eckert,

Affiliation Gittlen Cancer Research Institute & Department of Pathology, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania, United States of America
⨯
Ali R. Zomorrodi,

Affiliation Department of Chemical Engineering, Pennsylvania State University, University Park, Pennsylvania, United States of America
⨯
Ping Xin,

Affiliation Gittlen Cancer Research Institute & Department of Pathology, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania, United States of America
⨯
Weihua Pan,

Affiliation Gittlen Cancer Research Institute & Department of Pathology, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania, United States of America
⨯
Debra A. Shearer,

Affiliation Department of Obstetrics & Gynecology, Pennsylvania State University, Hershey, Pennsylvania, United States of America
⨯
Judith Weisz,

Affiliation Department of Obstetrics & Gynecology, Pennsylvania State University, Hershey, Pennsylvania, United States of America
⨯
Costas D. Maranus,

Affiliation Department of Chemical Engineering, Pennsylvania State University, University Park, Pennsylvania, United States of America
⨯
Gary A. Clawson

* E-mail: gac4@psu.edu

Affiliations Gittlen Cancer Research Institute & Department of Pathology, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania, United States of America, Materials Research Institute, Pennsylvania State University, University Park, Pennsylvania, United States of America
⨯

Down-Regulation of HtrA1 Activates the Epithelial-Mesenchymal Transition and ATM DNA Damage Response Pathways

Ning Wang,
Kristin A. Eckert,
Ali R. Zomorrodi,
Ping Xin,
Weihua Pan,
Debra A. Shearer,
Judith Weisz,
Costas D. Maranus,
Gary A. Clawson

Published: June 26, 2012
https://doi.org/10.1371/journal.pone.0039446

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Breast cancer
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DNA methylation
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Cell staining
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Gene expression
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DNA damage
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Immunohistochemistry techniques
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Oxidative stress
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