Shear Forces during Blast, Not Abrupt Changes in Pressure Alone, Generate Calcium Activity in Human Brain Cells

Rea Ravin; Paul S. Blank; Alex Steinkamp; Shay M. Rappaport; Nitay Ravin; Ludmila Bezrukov; Hugo Guerrero-Cazares; Alfredo Quinones-Hinojosa; Sergey M. Bezrukov; Joshua Zimmerberg

doi:10.1371/journal.pone.0039421

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Peer-reviewed

Research Article

Shear Forces during Blast, Not Abrupt Changes in Pressure Alone, Generate Calcium Activity in Human Brain Cells

Rea Ravin,

Affiliation Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Paul S. Blank,

Affiliations Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America, Center for Neuroscience and Regenerative Medicine at the Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
⨯
Alex Steinkamp,

Affiliation Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Shay M. Rappaport,

Affiliations Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America, Center for Neuroscience and Regenerative Medicine at the Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
⨯
Nitay Ravin,

Affiliation Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Ludmila Bezrukov,

Affiliation Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Hugo Guerrero-Cazares,

Affiliation Department of Neurosurgery, Johns Hopkins University, Baltimore, Maryland, United States of America
⨯
Alfredo Quinones-Hinojosa,

Affiliation Department of Neurosurgery, Johns Hopkins University, Baltimore, Maryland, United States of America
⨯
Sergey M. Bezrukov,

Affiliations Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America, Center for Neuroscience and Regenerative Medicine at the Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
⨯
Joshua Zimmerberg

* E-mail: zimmerbj@mail.nih.gov

Affiliations Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America, Center for Neuroscience and Regenerative Medicine at the Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
⨯

Shear Forces during Blast, Not Abrupt Changes in Pressure Alone, Generate Calcium Activity in Human Brain Cells

Rea Ravin,
Paul S. Blank,
Alex Steinkamp,
Shay M. Rappaport,
Nitay Ravin,
Ludmila Bezrukov,
Hugo Guerrero-Cazares,
Alfredo Quinones-Hinojosa,
Sergey M. Bezrukov,
Joshua Zimmerberg

Published: June 29, 2012
https://doi.org/10.1371/journal.pone.0039421

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Shear stresses
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Traumatic brain injury
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Calcium imaging
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Calcium signaling
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Central nervous system
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Cell membranes
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Brain damage
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Cell cultures
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