Abortive Autophagy Induces Endoplasmic Reticulum Stress and Cell Death in Cancer Cells

Sofie Claerhout; Bhaskar Dutta; Wouter Bossuyt; Fan Zhang; Catherine Nguyen-Charles; Jennifer B. Dennison; Qinghua Yu; Shuangxing Yu; Gábor Balázsi; Yiling Lu; Gordon B. Mills

doi:10.1371/journal.pone.0039400

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Open Access

Peer-reviewed

Research Article

Abortive Autophagy Induces Endoplasmic Reticulum Stress and Cell Death in Cancer Cells

Sofie Claerhout ,

* E-mail: SAClaerhout@mdanderson.org

Affiliation Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Bhaskar Dutta,

Current address: Department of Defense Biotechnology High Performance Computing Software Applications Institute, United States Army Medical Research and Materiel Command, Frederick, Maryland, United States of America

Affiliation Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Wouter Bossuyt,

Affiliation Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Fan Zhang,

Affiliation Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Catherine Nguyen-Charles,

Affiliation Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Jennifer B. Dennison,

Affiliation Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Qinghua Yu,

Affiliation Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Shuangxing Yu,

Affiliation Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Gábor Balázsi,

Affiliation Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Yiling Lu,

Affiliation Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Gordon B. Mills

Affiliation Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯

Abortive Autophagy Induces Endoplasmic Reticulum Stress and Cell Death in Cancer Cells

Sofie Claerhout,
Bhaskar Dutta,
Wouter Bossuyt,
Fan Zhang,
Catherine Nguyen-Charles,
Jennifer B. Dennison,
Qinghua Yu,
Shuangxing Yu,
Gábor Balázsi,
Yiling Lu

Published: June 26, 2012
https://doi.org/10.1371/journal.pone.0039400

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Autophagic cell death
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Breast cancer
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Small interfering RNA
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Endoplasmic reticulum
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