Inhibition of CLIC4 Enhances Autophagy and Triggers Mitochondrial and ER Stress-Induced Apoptosis in Human Glioma U251 Cells under Starvation

Open Access

Peer-reviewed

Research Article

Jiateng Zhong ,

Contributed equally to this work with: Jiateng Zhong, Xiaoxia Kong

Affiliation Department of Pathophysiology, Norman Bethune College of Medicine, Jilin University, Changchun, Jilin, China
⨯
Xiaoxia Kong ,

Contributed equally to this work with: Jiateng Zhong, Xiaoxia Kong

Affiliation Institute of Hypoxia Medical Research, Teaching Center of Functional Experiment, Basic Medical School, Wenzhou Medical College, Wenzhou, China
⨯
Hongyu Zhang,

Affiliation School of Pharmacy, Wenzhou Medical College, Wenzhou, China
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Chunyan Yu,

Affiliation Department of Pathology, Basic Medical College, Beihua University, Jilin, China
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Ye Xu,

Affiliation Medical Research Laboratory, Jilin Medical College, Jilin, China
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Jinsong Kang,

Affiliation Department of Pathophysiology, Norman Bethune College of Medicine, Jilin University, Changchun, Jilin, China
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Huimei Yu,

Affiliation Department of Pathogenobiology, Norman Bethune College of Medicine, Jilin University, Changchun, Jilin, China
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Haowei Yi,

Affiliation Department of Pathophysiology, Norman Bethune College of Medicine, Jilin University, Changchun, Jilin, China
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Xiaochun Yang,

Affiliation Department of Pathophysiology, Norman Bethune College of Medicine, Jilin University, Changchun, Jilin, China
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Liankun Sun

* E-mail: sunlk@jlu.edu.cn

Affiliation Department of Pathophysiology, Norman Bethune College of Medicine, Jilin University, Changchun, Jilin, China
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Apoptosis
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Autophagic cell death
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Small interfering RNA
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Transfection
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Cell staining
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Mitochondria
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Glioma cells
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Protein expression
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