Structure-Function Analysis of Human TYW2 Enzyme Required for the Biosynthesis of a Highly Modified Wybutosine (yW) Base in Phenylalanine-tRNA

• Virginia Rodriguez ,

  Contributed equally to this work with: Virginia Rodriguez, Sona Vasudevan, Akiko Noma

  Affiliation Cancer Genetics Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America

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• Sona Vasudevan ,

  Contributed equally to this work with: Virginia Rodriguez, Sona Vasudevan, Akiko Noma

  Affiliation Department of Biochemistry and Molecular Cellular Biology, Georgetown University Medical Center, Washington, District of Columbia, United States of America

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• Akiko Noma ,

  Contributed equally to this work with: Virginia Rodriguez, Sona Vasudevan, Akiko Noma

  Affiliation Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan

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• Bradley A. Carlson,

  Affiliation Laboratory of Cancer Prevention, National Cancer Institute National Institutes of Health, Bethesda, Maryland, United States of America

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• Jeffrey E. Green,

  Affiliation Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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• Tsutomu Suzuki,

  Affiliation Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan

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• Settara C. Chandrasekharappa

  * E-mail: chandra@mail.nih.gov

  Affiliation Cancer Genetics Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America

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