The hTERT Promoter Enhances the Antitumor Activity of an Oncolytic Adenovirus under a Hypoxic Microenvironment

Yuuri Hashimoto; Hiroshi Tazawa; Fuminori Teraishi; Toru Kojima; Yuichi Watanabe; Futoshi Uno; Shuya Yano; Yasuo Urata; Shunsuke Kagawa; Toshiyoshi Fujiwara

doi:10.1371/journal.pone.0039292

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Open Access

Peer-reviewed

Research Article

The hTERT Promoter Enhances the Antitumor Activity of an Oncolytic Adenovirus under a Hypoxic Microenvironment

Yuuri Hashimoto,

Affiliation Department of Gastroenterological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
⨯
Hiroshi Tazawa,

Affiliations Department of Gastroenterological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan, Center for Gene and Cell Therapy, Okayama University Hospital, Okayama, Japan
⨯
Fuminori Teraishi,

Affiliation Department of Gastroenterological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
⨯
Toru Kojima,

Affiliation Department of Gastroenterological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
⨯
Yuichi Watanabe,

Affiliation Department of Gastroenterological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
⨯
Futoshi Uno,

Affiliation Department of Gastroenterological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
⨯
Shuya Yano,

Affiliation Department of Gastroenterological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
⨯
Yasuo Urata,

Affiliation Oncolys BioPharma, Inc., Tokyo, Japan
⨯
Shunsuke Kagawa,

Affiliation Department of Gastroenterological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
⨯
Toshiyoshi Fujiwara

* E-mail: toshi_f@md.okayama-u.ac.jp

Affiliation Department of Gastroenterological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
⨯

The hTERT Promoter Enhances the Antitumor Activity of an Oncolytic Adenovirus under a Hypoxic Microenvironment

Yuuri Hashimoto,
Hiroshi Tazawa,
Fuminori Teraishi,
Toru Kojima,
Yuichi Watanabe,
Futoshi Uno,
Shuya Yano,
Yasuo Urata,
Shunsuke Kagawa,
Toshiyoshi Fujiwara

Published: June 15, 2012
https://doi.org/10.1371/journal.pone.0039292

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Hypoxia
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Cancers and neoplasms
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Adenoviruses
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Medical hypoxia
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Oncolytic viruses
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DAPI staining
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