Microglial Activation Correlates with Disease Progression and Upper Motor Neuron Clinical Symptoms in Amyotrophic Lateral Sclerosis

Johannes Brettschneider; Jon B. Toledo; Vivianna M. Van Deerlin; Lauren Elman; Leo McCluskey; Virginia M.-Y. Lee; John Q. Trojanowski

doi:10.1371/journal.pone.0039216

Loading metrics

Open Access

Peer-reviewed

Research Article

Microglial Activation Correlates with Disease Progression and Upper Motor Neuron Clinical Symptoms in Amyotrophic Lateral Sclerosis

Johannes Brettschneider ,

* E-mail: Johannes.brettschneider@uni-ulm.de

Affiliations Center for Neurodegenerative Disease Research (CNDR), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Neurology, University of Ulm, Ulm, Germany
⨯
Jon B. Toledo,

Affiliations Center for Neurodegenerative Disease Research (CNDR), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Vivianna M. Van Deerlin,

Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Lauren Elman,

Affiliation Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Leo McCluskey,

Affiliation Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Virginia M.-Y. Lee,

Affiliations Center for Neurodegenerative Disease Research (CNDR), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
John Q. Trojanowski

Affiliations Center for Neurodegenerative Disease Research (CNDR), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯

Microglial Activation Correlates with Disease Progression and Upper Motor Neuron Clinical Symptoms in Amyotrophic Lateral Sclerosis

Johannes Brettschneider,
Jon B. Toledo,
Vivianna M. Van Deerlin,
Lauren Elman,
Leo McCluskey,
Virginia M.-Y. Lee,
John Q. Trojanowski

Published: June 14, 2012
https://doi.org/10.1371/journal.pone.0039216

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Central nervous system
Is the Subject Area "Central nervous system" applicable to this article?

Thanks for your feedback.
Microglial cells
Is the Subject Area "Microglial cells" applicable to this article?

Thanks for your feedback.
Clinical pathology
Is the Subject Area "Clinical pathology" applicable to this article?

Thanks for your feedback.
Motor cortex
Is the Subject Area "Motor cortex" applicable to this article?

Thanks for your feedback.
Spinal cord
Is the Subject Area "Spinal cord" applicable to this article?

Thanks for your feedback.
Amyotrophic lateral sclerosis
Is the Subject Area "Amyotrophic lateral sclerosis" applicable to this article?

Thanks for your feedback.
Autopsy
Is the Subject Area "Autopsy" applicable to this article?

Thanks for your feedback.
Reflexes
Is the Subject Area "Reflexes" applicable to this article?

Thanks for your feedback.