Engineering of Three-Finger Fold Toxins Creates Ligands with Original Pharmacological Profiles for Muscarinic and Adrenergic Receptors

Carole Fruchart-Gaillard; Gilles Mourier; Guillaume Blanchet; Laura Vera; Nicolas Gilles; Renée Ménez; Elodie Marcon; Enrico A. Stura; Denis Servent

doi:10.1371/journal.pone.0039166

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Open Access

Peer-reviewed

Research Article

Engineering of Three-Finger Fold Toxins Creates Ligands with Original Pharmacological Profiles for Muscarinic and Adrenergic Receptors

Carole Fruchart-Gaillard ,

Contributed equally to this work with: Carole Fruchart-Gaillard, Gilles Mourier

Affiliation CEA, iBiTecS, Service d’Ingénierie Moléculaire des Protéines, Laboratoire de Toxinologie Moléculaire et Biotechnologies, Gif-sur-Yvette, France
⨯
Gilles Mourier ,

Contributed equally to this work with: Carole Fruchart-Gaillard, Gilles Mourier

Affiliation CEA, iBiTecS, Service d’Ingénierie Moléculaire des Protéines, Laboratoire de Toxinologie Moléculaire et Biotechnologies, Gif-sur-Yvette, France
⨯
Guillaume Blanchet,

Affiliations CEA, iBiTecS, Service d’Ingénierie Moléculaire des Protéines, Laboratoire de Toxinologie Moléculaire et Biotechnologies, Gif-sur-Yvette, France, Université Pierre et Marie Curie, Paris, France
⨯
Laura Vera,

Affiliation CEA, iBiTecS, Service d’Ingénierie Moléculaire des Protéines, Laboratoire de Toxinologie Moléculaire et Biotechnologies, Gif-sur-Yvette, France
⨯
Nicolas Gilles,

Affiliation CEA, iBiTecS, Service d’Ingénierie Moléculaire des Protéines, Laboratoire de Toxinologie Moléculaire et Biotechnologies, Gif-sur-Yvette, France
⨯
Renée Ménez,

Affiliation CEA, iBiTecS, Service d’Ingénierie Moléculaire des Protéines, Laboratoire de Toxinologie Moléculaire et Biotechnologies, Gif-sur-Yvette, France
⨯
Elodie Marcon,

Affiliation CEA, iBiTecS, Service d’Ingénierie Moléculaire des Protéines, Laboratoire de Toxinologie Moléculaire et Biotechnologies, Gif-sur-Yvette, France
⨯
Enrico A. Stura,

Affiliation CEA, iBiTecS, Service d’Ingénierie Moléculaire des Protéines, Laboratoire de Toxinologie Moléculaire et Biotechnologies, Gif-sur-Yvette, France
⨯
Denis Servent

* E-mail: denis.servent@cea.fr

Affiliation CEA, iBiTecS, Service d’Ingénierie Moléculaire des Protéines, Laboratoire de Toxinologie Moléculaire et Biotechnologies, Gif-sur-Yvette, France
⨯

Engineering of Three-Finger Fold Toxins Creates Ligands with Original Pharmacological Profiles for Muscarinic and Adrenergic Receptors

Carole Fruchart-Gaillard,
Gilles Mourier,
Guillaume Blanchet,
Laura Vera,
Nicolas Gilles,
Renée Ménez,
Elodie Marcon,
Enrico A. Stura,
Denis Servent

Published: June 14, 2012
https://doi.org/10.1371/journal.pone.0039166

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