The IkappaB Kinase Family Phosphorylates the Parkinson’s Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling

Nicolas Dzamko; Francisco Inesta-Vaquera; Jiazhen Zhang; Chengsong Xie; Huaibin Cai; Simon Arthur; Li Tan; Hwanguen Choi; Nathanael Gray; Philip Cohen; Patrick Pedrioli; Kristopher Clark; Dario R. Alessi

doi:10.1371/journal.pone.0039132

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Peer-reviewed

Research Article

The IkappaB Kinase Family Phosphorylates the Parkinson’s Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling

Nicolas Dzamko ,

* E-mail: n.dzamko@neura.edu.au (ND); d.r.alessi@dundee.ac.uk DRA

Affiliation MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, Scotland
⨯
Francisco Inesta-Vaquera,

Affiliation MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, Scotland
⨯
Jiazhen Zhang,

Affiliation MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, Scotland
⨯
Chengsong Xie,

Affiliation Transgenic Section, Laboratory of Neurogenetics, National Institute of Aging, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Huaibin Cai,

Affiliation Transgenic Section, Laboratory of Neurogenetics, National Institute of Aging, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Simon Arthur,

Affiliation MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, Scotland
⨯
Li Tan,

Affiliations Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Biological Chemistry and Molecular Pharmacology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Hwanguen Choi,

Affiliations Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Biological Chemistry and Molecular Pharmacology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Nathanael Gray,

Affiliations Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Biological Chemistry and Molecular Pharmacology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Philip Cohen,

Affiliation MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, Scotland
⨯
Patrick Pedrioli,

Affiliation Scottish Institute of Life Sciences, College of Life Sciences, University of Dundee, Dow Street, Dundee Scotland
⨯
Kristopher Clark,

Affiliation MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, Scotland
⨯
Dario R. Alessi

* E-mail: n.dzamko@neura.edu.au (ND); d.r.alessi@dundee.ac.uk DRA

Affiliation MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, Scotland
⨯

The IkappaB Kinase Family Phosphorylates the Parkinson’s Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling

Nicolas Dzamko,
Francisco Inesta-Vaquera,
Jiazhen Zhang,
Chengsong Xie,
Huaibin Cai,
Simon Arthur,
Li Tan,
Hwanguen Choi,
Nathanael Gray,
Philip Cohen

Published: June 18, 2012
https://doi.org/10.1371/journal.pone.0039132

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Phosphorylation
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Macrophages
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Cytokines
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Immunoprecipitation
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Immune receptor signaling
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Toll-like receptors
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Parkinson disease
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