Simvastatin Reduces Endotoxin-Induced Acute Lung Injury by Decreasing Neutrophil Recruitment and Radical Formation

Jochen Grommes; Santosh Vijayan; Maik Drechsler; Helene Hartwig; Matthias Mörgelin; Rolf Dembinski; Michael Jacobs; Thomas Andreas Koeppel; Marcel Binnebösel; Christian Weber; Oliver Soehnlein

doi:10.1371/journal.pone.0038917

Loading metrics

Open Access

Peer-reviewed

Research Article

Simvastatin Reduces Endotoxin-Induced Acute Lung Injury by Decreasing Neutrophil Recruitment and Radical Formation

Jochen Grommes ,

* E-mail: jgrommes@ukaachen.de (JG); oliver.soehnlein@med.uni-muenchen.de (OS)

Affiliations Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen, Aachen, Germany, European Vascular Center Aachen-Maastricht, RWTH Aachen, Aachen Germany and Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Santosh Vijayan,

Affiliation Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen, Aachen, Germany
⨯
Maik Drechsler,

Affiliation Institute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, Munich, Germany
⨯
Helene Hartwig,

Affiliation Institute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, Munich, Germany
⨯
Matthias Mörgelin,

Affiliation Division of Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden
⨯
Rolf Dembinski,

Affiliation Department of Intensive Care Medicine, RWTH Aachen, Aachen, Germany
⨯
Michael Jacobs,

Affiliation European Vascular Center Aachen-Maastricht, RWTH Aachen, Aachen Germany and Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Thomas Andreas Koeppel,

Affiliation European Vascular Center Aachen-Maastricht, RWTH Aachen, Aachen Germany and Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Marcel Binnebösel,

Affiliation Department of General, Visceral and Transplantation Surgery, RWTH Aachen, Aachen, Germany
⨯
Christian Weber,

Affiliations Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen, Aachen, Germany, Institute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, Munich, Germany, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
⨯
Oliver Soehnlein

* E-mail: jgrommes@ukaachen.de (JG); oliver.soehnlein@med.uni-muenchen.de (OS)

Affiliations Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen, Aachen, Germany, Institute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, Munich, Germany, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
⨯

Simvastatin Reduces Endotoxin-Induced Acute Lung Injury by Decreasing Neutrophil Recruitment and Radical Formation

Jochen Grommes,
Santosh Vijayan,
Maik Drechsler,
Helene Hartwig,
Matthias Mörgelin,
Rolf Dembinski,
Michael Jacobs,
Thomas Andreas Koeppel,
Marcel Binnebösel,
Christian Weber

Published: June 11, 2012
https://doi.org/10.1371/journal.pone.0038917

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Neutrophils
Is the Subject Area "Neutrophils" applicable to this article?

Thanks for your feedback.
Statins
Is the Subject Area "Statins" applicable to this article?

Thanks for your feedback.
Inhalation
Is the Subject Area "Inhalation" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Flow cytometry
Is the Subject Area "Flow cytometry" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Vascular permeability
Is the Subject Area "Vascular permeability" applicable to this article?

Thanks for your feedback.
Permeability
Is the Subject Area "Permeability" applicable to this article?

Thanks for your feedback.