Label-Free Imaging of Basement Membranes Differentiates Normal, Precancerous, and Cancerous Colonic Tissues by Second-Harmonic Generation Microscopy

Shuangmu Zhuo; Jun Yan; Gang Chen; Hong Shi; Xiaoqin Zhu; Jianping Lu; Jianxin Chen; Shusen Xie

doi:10.1371/journal.pone.0038655

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Peer-reviewed

Research Article

Label-Free Imaging of Basement Membranes Differentiates Normal, Precancerous, and Cancerous Colonic Tissues by Second-Harmonic Generation Microscopy

Shuangmu Zhuo ,

Contributed equally to this work with: Shuangmu Zhuo, Jun Yan, Gang Chen

Affiliation Institute of Laser and Optoelectronics Technology, Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Normal University, Fuzhou, China
⨯
Jun Yan ,

Contributed equally to this work with: Shuangmu Zhuo, Jun Yan, Gang Chen

Affiliation Department of Surgery, Fujian Provincial Tumor Hospital, Fuzhou, China
⨯
Gang Chen ,

Contributed equally to this work with: Shuangmu Zhuo, Jun Yan, Gang Chen

Affiliation Department of Pathology, Fujian Provincial Tumor Hospital, Fuzhou, China
⨯
Hong Shi,

Affiliation Department of Endoscopy, Fujian Provincial Tumor Hospital, Fuzhou, China
⨯
Xiaoqin Zhu,

Affiliation Institute of Laser and Optoelectronics Technology, Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Normal University, Fuzhou, China
⨯
Jianping Lu,

Affiliation Department of Pathology, Fujian Provincial Tumor Hospital, Fuzhou, China
⨯
Jianxin Chen ,

* E-mail: chenjianxin@fjnu.edu.cn (JC); ssxie@fjnu.edu.cn (SX)

Affiliation Institute of Laser and Optoelectronics Technology, Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Normal University, Fuzhou, China
⨯
Shusen Xie

* E-mail: chenjianxin@fjnu.edu.cn (JC); ssxie@fjnu.edu.cn (SX)

Affiliation Institute of Laser and Optoelectronics Technology, Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Normal University, Fuzhou, China
⨯

Label-Free Imaging of Basement Membranes Differentiates Normal, Precancerous, and Cancerous Colonic Tissues by Second-Harmonic Generation Microscopy

Shuangmu Zhuo,
Jun Yan,
Gang Chen,
Hong Shi,
Xiaoqin Zhu,
Jianping Lu,
Jianxin Chen,
Shusen Xie

Published: June 8, 2012
https://doi.org/10.1371/journal.pone.0038655

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Colon
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