µ-Calpain Conversion of Antiapoptotic Bfl-1 (BCL2A1) into a Prodeath Factor Reveals Two Distinct alpha-Helices Inducing Mitochondria-Mediated Apoptosis

Juan García Valero; Aurélie Cornut-Thibaut; Romain Jugé; Anne-Laure Debaud; Diana Giménez; Germain Gillet; Nathalie Bonnefoy-Bérard; Jesús Salgado; Gilles Salles; Abdel Aouacheria; Jérôme Kucharczak

doi:10.1371/journal.pone.0038620

Loading metrics

Open Access

Peer-reviewed

Research Article

µ-Calpain Conversion of Antiapoptotic Bfl-1 (BCL2A1) into a Prodeath Factor Reveals Two Distinct alpha-Helices Inducing Mitochondria-Mediated Apoptosis

Juan García Valero ,

Contributed equally to this work with: Juan García Valero, Aurélie Cornut-Thibaut

Affiliation Institut de Biologie et Chimie des Protéines (IBCP), CNRS UMR 5086, Université Lyon 1, IFR 128, Lyon, France
⨯
Aurélie Cornut-Thibaut ,

Contributed equally to this work with: Juan García Valero, Aurélie Cornut-Thibaut

Affiliation Laboratoire de Biologie Moléculaire de la Cellule (LBMC), Ecole Normale Supérieure de Lyon, CNRS UMR 5239, SFR Biosciences Gerland-Lyon Sud US8/UMS3444, Lyon, France
⨯
Romain Jugé,

Affiliation Laboratoire de Biologie Moléculaire de la Cellule (LBMC), Ecole Normale Supérieure de Lyon, CNRS UMR 5239, SFR Biosciences Gerland-Lyon Sud US8/UMS3444, Lyon, France
⨯
Anne-Laure Debaud,

Affiliation Inserm U851, Université Lyon 1, IFR128, Lyon, France
⨯
Diana Giménez,

Affiliation Instituto de Ciencia Molecular, Universidad de Valencia, Paterna (Valencia), Spain
⨯
Germain Gillet,

Affiliation Centre de recherche en cancérologie de Lyon, Centre Léon Bérard, Université Lyon 1, Inserm U1052, UMS3453 CNRS, Lyon, France
⨯
Nathalie Bonnefoy-Bérard,

Affiliation Inserm U851, Université Lyon 1, IFR128, Lyon, France
⨯
Jesús Salgado,

Affiliations Instituto de Ciencia Molecular, Universidad de Valencia, Paterna (Valencia), Spain, Departamento de Bioquímica y Biología Molecular, Universidad de Valencia, Burjassot (Valencia), Spain
⨯
Gilles Salles,

Affiliation Laboratoire de Biologie Moléculaire de la Cellule (LBMC), Ecole Normale Supérieure de Lyon, CNRS UMR 5239, SFR Biosciences Gerland-Lyon Sud US8/UMS3444, Lyon, France
⨯
Abdel Aouacheria,

Affiliation Laboratoire de Biologie Moléculaire de la Cellule (LBMC), Ecole Normale Supérieure de Lyon, CNRS UMR 5239, SFR Biosciences Gerland-Lyon Sud US8/UMS3444, Lyon, France
⨯
Jérôme Kucharczak

* E-mail: jerome.kucharczak@ens-lyon.fr

Affiliation Laboratoire de Biologie Moléculaire de la Cellule (LBMC), Ecole Normale Supérieure de Lyon, CNRS UMR 5239, SFR Biosciences Gerland-Lyon Sud US8/UMS3444, Lyon, France
⨯

µ-Calpain Conversion of Antiapoptotic Bfl-1 (BCL2A1) into a Prodeath Factor Reveals Two Distinct alpha-Helices Inducing Mitochondria-Mediated Apoptosis

Juan García Valero,
Aurélie Cornut-Thibaut,
Romain Jugé,
Anne-Laure Debaud,
Diana Giménez,
Germain Gillet,
Nathalie Bonnefoy-Bérard,
Jesús Salgado,
Gilles Salles,
Abdel Aouacheria

Published: June 20, 2012
https://doi.org/10.1371/journal.pone.0038620

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Mitochondria
Is the Subject Area "Mitochondria" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Cell death
Is the Subject Area "Cell death" applicable to this article?

Thanks for your feedback.
Cell staining
Is the Subject Area "Cell staining" applicable to this article?

Thanks for your feedback.
Recombinant proteins
Is the Subject Area "Recombinant proteins" applicable to this article?

Thanks for your feedback.
Outer membrane proteins
Is the Subject Area "Outer membrane proteins" applicable to this article?

Thanks for your feedback.
Protein structure
Is the Subject Area "Protein structure" applicable to this article?

Thanks for your feedback.