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Open Access

Peer-reviewed

Research Article

Plakophilin3 Loss Leads to an Increase in PRL3 Levels Promoting K8 Dephosphorylation, Which Is Required for Transformation and Metastasis

Nileema Khapare ,

Contributed equally to this work with: Nileema Khapare, Samrat T. Kundu, Lalit Sehgal

Affiliation KS215, Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar Node, Navi Mumbai, Maharashtra, India
⨯
Samrat T. Kundu ,

Contributed equally to this work with: Nileema Khapare, Samrat T. Kundu, Lalit Sehgal

Current address: Department of Thoracic H&N Medical Oncology, MD Anderson Cancer Center, Houston, Texas, United States of America

Affiliation KS215, Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar Node, Navi Mumbai, Maharashtra, India
⨯
Lalit Sehgal ,

Contributed equally to this work with: Nileema Khapare, Samrat T. Kundu, Lalit Sehgal

Affiliation KS215, Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar Node, Navi Mumbai, Maharashtra, India
⨯
Mugdha Sawant,

Affiliation KS215, Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar Node, Navi Mumbai, Maharashtra, India
⨯
Rashmi Priya,

Affiliation KS215, Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar Node, Navi Mumbai, Maharashtra, India
⨯
Prajakta Gosavi,

Affiliation KS215, Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar Node, Navi Mumbai, Maharashtra, India
⨯
Neha Gupta,

Affiliation KS215, Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar Node, Navi Mumbai, Maharashtra, India
⨯
Hunain Alam,

Affiliation KS215, Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar Node, Navi Mumbai, Maharashtra, India
⨯
Madhura Karkhanis,

Affiliation Pharmacology Department, Piramal Life Sciences Ltd., Mumbai, Maharashtra, India
⨯
Nishigandha Naik,

Affiliation Pharmacology Department, Piramal Life Sciences Ltd., Mumbai, Maharashtra, India
⨯
Milind M. Vaidya,

Affiliation KS215, Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar Node, Navi Mumbai, Maharashtra, India
⨯
Sorab N. Dalal

* E-mail: sdalal@actrec.gov.in

Affiliation KS215, Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar Node, Navi Mumbai, Maharashtra, India
⨯

Plakophilin3 Loss Leads to an Increase in PRL3 Levels Promoting K8 Dephosphorylation, Which Is Required for Transformation and Metastasis

Nileema Khapare,
Samrat T. Kundu,
Lalit Sehgal,
Mugdha Sawant,
Rashmi Priya,
Prajakta Gosavi,
Neha Gupta,
Hunain Alam,
Madhura Karkhanis,
Nishigandha Naik

x

Published: June 6, 2012
https://doi.org/10.1371/journal.pone.0038561

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Cloning
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Metastasis
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Transfection
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Immunoprecipitation
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Lung and intrathoracic tumors
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Phosphorylation
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Keratins
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Secondary lung tumors
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