Potential of Host Markers Produced by Infection Phase-Dependent Antigen-Stimulated Cells for the Diagnosis of Tuberculosis in a Highly Endemic Area

Novel N. Chegou; Paulin N. Essone; Andre G. Loxton; Kim Stanley; Gillian F. Black; Gian D. van der Spuy; Paul D. van Helden; Kees L. Franken; Shreemanta K. Parida; Michel R. Klein; Stefan H. E. Kaufmann; Tom H. M. Ottenhoff; Gerhard Walzl

doi:10.1371/journal.pone.0038501

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Open Access

Peer-reviewed

Research Article

Potential of Host Markers Produced by Infection Phase-Dependent Antigen-Stimulated Cells for the Diagnosis of Tuberculosis in a Highly Endemic Area

Novel N. Chegou ,

* E-mail: novel@sun.ac.za

Affiliation DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
⨯
Paulin N. Essone,

Affiliation DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
⨯
Andre G. Loxton,

Affiliation DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
⨯
Kim Stanley,

Affiliation DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
⨯
Gillian F. Black,

Affiliation DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
⨯
Gian D. van der Spuy,

Affiliation DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
⨯
Paul D. van Helden,

Affiliation DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
⨯
Kees L. Franken,

Affiliation Department of Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands
⨯
Shreemanta K. Parida,

Affiliation Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
⨯
Michel R. Klein,

Affiliation Department of Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands
⨯
Stefan H. E. Kaufmann,

Affiliation Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
⨯
Tom H. M. Ottenhoff,

Affiliation Department of Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands
⨯
Gerhard Walzl

Affiliation DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
⨯

Potential of Host Markers Produced by Infection Phase-Dependent Antigen-Stimulated Cells for the Diagnosis of Tuberculosis in a Highly Endemic Area

Novel N. Chegou,
Paulin N. Essone,
Andre G. Loxton,
Kim Stanley,
Gillian F. Black,
Gian D. van der Spuy,
Paul D. van Helden,
Kees L. Franken,
Shreemanta K. Parida,
Michel R. Klein

Published: June 5, 2012
https://doi.org/10.1371/journal.pone.0038501

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