An Improved Protocol for Efficient Engraftment in NOD/LTSZ-SCIDIL-2RγNULL Mice Allows HIV Replication and Development of Anti-HIV Immune Responses

Maneesh Singh; Pratibha Singh; Gilles Gaudray; Lucia Musumeci; Caroline Thielen; Dolores Vaira; Claire Vandergeeten; Laurence Delacroix; Ellen Van Gulck; Guido Vanham; Laurence de Leval; Souad Rahmouni; Michel Moutschen

doi:10.1371/journal.pone.0038491

Loading metrics

Open Access

Peer-reviewed

Research Article

An Improved Protocol for Efficient Engraftment in NOD/LTSZ-SCIDIL-2Rγ^NULL Mice Allows HIV Replication and Development of Anti-HIV Immune Responses

Maneesh Singh,

Affiliation Immunology and infectious diseases unit GIGA-I3, University of Liege, Liege, Belgium
⨯
Pratibha Singh,

Affiliation Immunology and infectious diseases unit GIGA-I3, University of Liege, Liege, Belgium
⨯
Gilles Gaudray,

Affiliation Immunology and infectious diseases unit GIGA-I3, University of Liege, Liege, Belgium
⨯
Lucia Musumeci,

Affiliation Immunology and infectious diseases unit GIGA-I3, University of Liege, Liege, Belgium
⨯
Caroline Thielen,

Affiliation Experimental pathology unit GIGA-Cancer, University of Liege, Liege, Belgium
⨯
Dolores Vaira,

Affiliation Liege AIDS reference center, University of Liege, Liege, Belgium
⨯
Claire Vandergeeten,

Current address: Vaccine and Gene Therapy Institute-Florida, Port Sainte-Lucie, Florida, United States of America

Affiliation Immunology and infectious diseases unit GIGA-I3, University of Liege, Liege, Belgium
⨯
Laurence Delacroix,

Affiliation Immunology and infectious diseases unit GIGA-I3, University of Liege, Liege, Belgium
⨯
Ellen Van Gulck,

Affiliation Virology Unit Institute of Tropical Medicine, University of Antwerpen, Antwerpen, Antwerpen, Belgium
⨯
Guido Vanham,

Affiliation Virology Unit Institute of Tropical Medicine, University of Antwerpen, Antwerpen, Antwerpen, Belgium
⨯
Laurence de Leval,

Current address: Pathologie Clinique, Institut Universitaire de pathologie de Lausanne, Lausanne, Switzerland

Affiliation Experimental pathology unit GIGA-Cancer, University of Liege, Liege, Belgium
⨯
Souad Rahmouni,

Affiliation Immunology and infectious diseases unit GIGA-I3, University of Liege, Liege, Belgium
⨯
Michel Moutschen

* E-mail: michel.moutschen@ulg.ac.be

Affiliation Immunology and infectious diseases unit GIGA-I3, University of Liege, Liege, Belgium
⨯

An Improved Protocol for Efficient Engraftment in NOD/LTSZ-SCIDIL-2Rγ^NULL Mice Allows HIV Replication and Development of Anti-HIV Immune Responses

Maneesh Singh,
Pratibha Singh,
Gilles Gaudray,
Lucia Musumeci,
Caroline Thielen,
Dolores Vaira,
Claire Vandergeeten,
Laurence Delacroix,
Ellen Van Gulck,
Guido Vanham

Published: June 4, 2012
https://doi.org/10.1371/journal.pone.0038491

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
T cells
Is the Subject Area "T cells" applicable to this article?

Thanks for your feedback.
HIV-1
Is the Subject Area "HIV-1" applicable to this article?

Thanks for your feedback.
Lymph nodes
Is the Subject Area "Lymph nodes" applicable to this article?

Thanks for your feedback.
Spleen
Is the Subject Area "Spleen" applicable to this article?

Thanks for your feedback.
HIV infections
Is the Subject Area "HIV infections" applicable to this article?

Thanks for your feedback.
Cytotoxic T cells
Is the Subject Area "Cytotoxic T cells" applicable to this article?

Thanks for your feedback.
Enzyme-linked immunoassays
Is the Subject Area "Enzyme-linked immunoassays" applicable to this article?

Thanks for your feedback.